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评估加速康复外科(ERAS)方案在复杂脊柱手术并发症和住院时间的应用:单中心研究。

Evaluation of ERAS protocol implementation on complex spine surgery complications and length of stay: a single institution study.

机构信息

Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Spine J. 2024 Oct;24(10):1811-1816. doi: 10.1016/j.spinee.2024.05.008. Epub 2024 Jun 4.

Abstract

BACKGROUND CONTEXT

With the goal of improving patient outcomes, the Integrated Spine Center at UT Southwestern Medical Center implemented an enhanced recovery after surgery (ERAS) protocol which includes pre- and postsurgery guidelines. Numerous studies have shown benefit of implementation of ERAS protocols to standardize perioperative care in line with best practices; however, the literature on complication rates, LOS, and readmissions shows mixed results.

PURPOSE

The goal of this study was to investigate the impact of the ERAS protocol implementation on complication rates in the perioperative period, as well as hospital and ICU length of stay and hospital re-admission rates.

STUDY DESIGN/SETTING: A retrospective cohort study was performed on all patients who underwent spine surgery between September 2016 and September 2021 at a single institution. Patients who met inclusion criteria were divided into non-ERAS and ERAS groups, and comparative statistics were used to evaluate ERAS protocol effectiveness.

PATIENT SAMPLE

All patients who underwent spine surgery at UT Southwestern between September 2016 and September 2021 were evaluated for inclusion in the study. The patient sample was further refined to include only complex patient cases which were able to receive the full ERAS protocol (nonemergent admissions).

OUTCOME MEASURES

Presence of absence of postoperative complications including surgical site infection, AKI, DVT, MI, sepsis, pneumonia, PE, stroke, shock, and other complications were compared between groups, as were hospital and ICU length of stay, and 7, 30, and 90 day readmissions. Self-reported or functional measures were not used in outcome evaluation.

METHODS

A database of patient and surgery characteristics was built using an EMR query tool with spot checks performed by the authors. Control and treatment groups were matched for gender, age, BMI, ASA score, and surgery type. Total number of complication rates was compared between ERAS and non-ERAS groups, and comparative statistics were used to determine significance.

RESULTS

Significant differences between ERAS versus non-ERAS groups were found in rates of UTI (6.8% vs 3.1%, respectively; p=.031), constipation (20.6% vs 11.4%, respectively; p=.001), and any complications (31.4% vs 19.4%, respectively; p<.001). There was no significant difference in the rates of other complications, in length of hospital or ICU stay, or readmissions at 7, 30, and 90 days.

CONCLUSIONS

Implementation of the ERAS protocol did not decrease complication rates or length of stay, and ERAS patients had significantly higher rates of UTI, constipation, and any complications. There may have been confounding factors due to the impact of COVID-19 on delivery of care, as well as misalignment between ERAS goals and outcome measures.

摘要

背景

为了改善患者的预后,UT 西南医学中心的综合脊柱中心实施了强化术后康复(ERAS)方案,其中包括术前和术后的指导方针。大量研究表明,实施 ERAS 方案可以使围手术期护理标准化,符合最佳实践,从而获益;然而,关于并发症发生率、住院时间(LOS)和再入院率的文献结果不一。

目的

本研究旨在探讨 ERAS 方案的实施对围手术期并发症发生率、住院时间、ICU 住院时间和再入院率的影响。

研究设计/地点:对 2016 年 9 月至 2021 年 9 月在一家机构接受脊柱手术的所有患者进行了回顾性队列研究。符合纳入标准的患者分为非 ERAS 组和 ERAS 组,采用比较统计学方法评估 ERAS 方案的效果。

患者样本

评估了 2016 年 9 月至 2021 年 9 月期间在 UT 西南接受脊柱手术的所有患者,以评估其纳入研究的情况。对患者样本进行了进一步的细化,仅纳入能够接受完整 ERAS 方案的复杂患者病例(非紧急入院)。

结果测量

比较了两组患者术后并发症(包括手术部位感染、急性肾损伤、深静脉血栓形成、心肌梗死、脓毒症、肺炎、肺栓塞、中风、休克和其他并发症)的有无,比较了住院和 ICU 住院时间,以及 7、30 和 90 天的再入院率。结局评估未使用自我报告或功能测量。

方法

使用电子病历查询工具建立了一个包含患者和手术特征的数据库,并由作者进行了抽查。对照和治疗组在性别、年龄、BMI、ASA 评分和手术类型方面进行了匹配。比较了 ERAS 组和非 ERAS 组的总并发症发生率,并采用比较统计学方法确定了差异的显著性。

结果

ERAS 组与非 ERAS 组在尿路感染(6.8%对 3.1%;p=.031)、便秘(20.6%对 11.4%;p=.001)和任何并发症(31.4%对 19.4%;p<.001)的发生率方面存在显著差异。两组间其他并发症、住院时间或 ICU 住院时间、7、30 和 90 天再入院率均无显著差异。

结论

实施 ERAS 方案并未降低并发症发生率或住院时间,ERAS 患者的尿路感染、便秘和任何并发症的发生率显著更高。由于 COVID-19 对护理的影响,以及 ERAS 目标与结局测量之间的不一致,可能存在混杂因素。

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