心血管免疫学期望：过去、现在和可预见的未来
The Emerging Field of Cardioimmunology: Past, Present and Foreseeable Future.
机构信息
Cardiovascular Division, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO.
出版信息
Circ Res. 2024 Jun 7;134(12):1663-1680. doi: 10.1161/CIRCRESAHA.123.323656. Epub 2024 Jun 6.
Abstract
Over the past 30 years, the field of cardioimmunology has moved from being dismissed as a field that was chasing an epiphenomenon of little biological consequence to a scientific discipline that is providing important new insights into the immunologic basis for hypertension, atherosclerosis, myocarditis, pericarditis, autoimmune heart disease, and heart failure. In this article, we will review the conceptual insights and technical breakthroughs that have allowed the field to move forward, as well as the clinical trials in the cardioimmunology space, to provide a historical context for the articles that will appear in the compendium that is focused on the interface between cardioimmunology, myocardial function, and disease.
摘要
在过去的 30 年里，心脏免疫学领域已经从一个被认为是追逐生物学意义不大的偶发现象的领域，发展成为一个提供重要新见解的科学学科，揭示了高血压、动脉粥样硬化、心肌炎、心包炎、自身免疫性心脏病和心力衰竭的免疫学基础。在本文中，我们将回顾推动该领域发展的概念性见解和技术突破，以及心脏免疫学领域的临床试验，为将出现在关注心脏免疫学、心肌功能和疾病之间界面的纲要中的文章提供历史背景。
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