Fernandes B J, Amato D, Goldfinger M
Gastroenterology. 1985 May;88(5 Pt 1):1267-70. doi: 10.1016/s0016-5085(85)80091-3.
A case of diffuse lymphomatous polyposis of the gastrointestinal tract is reported. The patient presented with abdominal pain and weight loss and x-rays revealed multiple polyps involving the entire gastrointestinal tract. Biopsies confirmed the diagnosis of lymphomatous polyposis. The patient also had involvement of the bone marrow and supraclavicular lymph node. Immunologically this lymphoma was characterized as a monoclonal proliferation of B lymphocytes bearing immunoglobulin M, type kappa. Diffuse lymphomatous polyposis of the gastrointestinal tract appears to be a generalized malignancy of uncommitted B cells of Peyer's patches. The migratory properties of these cells may account for the tendency to dissemination of lymphomatous polyposis. Diffuse lymphomatous polyposis of the gastrointestinal tract is a distinct entity, separate from the diffuse gastrointestinal lymphoma known as Mediterranean-type lymphoma.
本文报告一例胃肠道弥漫性淋巴瘤性息肉病。患者表现为腹痛和体重减轻，X线检查显示整个胃肠道有多个息肉。活检确诊为淋巴瘤性息肉病。患者还伴有骨髓和锁骨上淋巴结受累。免疫方面，该淋巴瘤的特征是带有κ型免疫球蛋白M的B淋巴细胞单克隆增殖。胃肠道弥漫性淋巴瘤性息肉病似乎是派尔集合淋巴结未分化B细胞的全身性恶性肿瘤。这些细胞的迁移特性可能解释了淋巴瘤性息肉病的播散倾向。胃肠道弥漫性淋巴瘤性息肉病是一种独特的疾病实体，与称为地中海型淋巴瘤的弥漫性胃肠道淋巴瘤不同。
