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The results of the use of CO2 laser in infertility surgery are encouraging. The unique properties of CO2 laser--precision of application, minimal bleeding, rapid healing, and minimal scarring--are beneficial for infertility surgery. It remains to be seen, however, whether the pregnancy rate in "laser patients" is superior to that in "conventional surgical patients." A well-controlled, randomized study and a long-term follow-up period are required to clarify this matter. A good understanding of the basic concepts of laser physics and a familiarity with the laser instruments are mandatory for the laser surgeon. A well-informed operating room staff will certainly be helpful in conducting effective and safe laser surgery. For example, all flammable and explosive material must be removed from the laser area, and protective coverings for the eyes must be worn by all personnel. Simplification, reduction in the bulk of the present instruments, and the development of a flexible CO2 laser transmission fiber that can be utilized through an endoscope will be beneficial.