Westerveld B D, Pals G, Défize J, Pronk J, Frants R R, Kreuning J, Eriksson A W, Meuwissen S G
Prog Clin Biol Res. 1985;173:201-12.
Previous studies in rats have shown that stomach carcinogens cause a decrease of total pepsinogen content and a decrease of the fastest pepsinogen isozymogen in gastric mucosa before the appearance of carcinoma. In man the presence of Pg 5, and in particular a strong Pg 5, appears to be associated with gastric cancer. Low serum PG I levels were found in patients with gastric cancer, atrophic gastritis, intestinal metaplasia and gastric polyp. In this chapter we review the literature and report our results of PG I isozymogen and serum PG I determinations in 500 patients with various gastric disorders. It is concluded that premalignant changes of the stomach are associated with the presence of a strong Pg 5 isozymogen and with a low serum PG I level.
以往对大鼠的研究表明，胃致癌物在癌出现之前会导致胃黏膜中总胃蛋白酶原含量降低以及最快的胃蛋白酶原同工酶减少。在人类中，Pg 5的存在，尤其是强Pg 5，似乎与胃癌有关。胃癌、萎缩性胃炎、肠化生和胃息肉患者的血清PG I水平较低。在本章中，我们回顾了文献并报告了500例各种胃部疾病患者的PG I同工酶和血清PG I测定结果。得出的结论是，胃的癌前病变与强Pg 5同工酶的存在以及血清PG I水平低有关。
