袖状胃切除术转为 Roux-en-Y 胃旁路术对胃食管反流病症状和质子泵抑制剂使用随时间演变的影响。
Results of sleeve gastrectomy conversion to Roux-en-Y gastric bypass on gastroesophageal reflux disease symptoms and proton pump inhibitors use evolution over time.
机构信息
University of Côte d'Azur, Nice, France; Department of Digestive Surgery, Hopital Archet 2, University Hospital of Nice, Nice, France.
Department of Digestive Surgery, Hopital Archet 2, University Hospital of Nice, Nice, France.
出版信息
J Gastrointest Surg. 2024 Sep;28(9):1412-1419. doi: 10.1016/j.gassur.2024.06.001. Epub 2024 Jun 7.
BACKGROUND
Although sleeve gastrectomy (SG) is associated with excellent results in the short term, it has been shown that it is plagued by weight regain and new onset or worsening of gastroesophageal reflux disease (GERD). These 2 clinical conditions are currently the 2 most frequent indications for revisional surgery. To date, only a few studies have focused exclusively on GERD. In a selected series of patients complaining of GERD symptoms after SG as a main complaint, we analyzed the efficacy of conversion to Roux-en-Y gastric bypass (RYGB), with a standardized surgical technique.
METHODS
This is a retrospective study including all consecutive cases of SG to RYGB conversion for GERD not controlled by medical treatment. We excluded all patients undergoing conversion for weight regain without GERD. Quality of life and GERD symptoms were evaluated at outpatient's clinic visits before and after surgery with 2 standardized questionnaires (Gastroesophageal Reflux Disease Questionnaire and Simplified Form 6).
RESULTS
This study showed that 70% of patients had complete resolution of GERD symptoms and 60% had completely discontinued proton pump inhibitors (PPIs). The conversion to RYGB resulted in a significant decrease in the rate of patients presenting daily symptoms of GERD and use of PPIs (10% and 16.6%, respectively; P < .019) and a dramatic increase in those without symptoms and no need for PPIs (70% and 60%, respectively; P < .001).
CONCLUSION
Conversion to RYGB is a good option for GERD complications after SG providing a high rate of symptom remission and PPI discontinuation. Conversion to RYGB in the setting of GERD complications after SG improves postoperative outcomes decreasing GERD symptoms and improving quality of life.
背景
袖状胃切除术(SG)在短期内效果显著,但已证实其存在体重反弹和胃食管反流病(GERD)新发病或恶化的问题。这两种临床情况是目前最常见的翻修手术指征。迄今为止,只有少数研究专门针对 GERD 进行了研究。在一组以 GERD 症状为主诉的接受 SG 治疗后出现 GERD 症状的患者中,我们分析了将其转换为 Roux-en-Y 胃旁路术(RYGB)的效果,采用了标准化的手术技术。
方法
这是一项回顾性研究,包括所有因 GERD 而未通过药物治疗控制的 SG 转为 RYGB 的连续病例。我们排除了所有因 GERD 以外的体重反弹而进行转换的患者。在手术前后的门诊就诊时,使用 2 种标准化问卷(胃食管反流病问卷和简化 6 项问卷)评估生活质量和 GERD 症状。
结果
本研究显示,70%的患者 GERD 症状完全缓解,60%的患者完全停止使用质子泵抑制剂(PPIs)。将 SG 转为 RYGB 后,出现 GERD 每日症状和使用 PPI 的患者比例显著降低(分别为 10%和 16.6%;P<.019),而无症状和无需使用 PPI 的患者比例显著增加(分别为 70%和 60%;P<.001)。
结论
SG 后出现 GERD 并发症时转为 RYGB 是一种较好的选择,可使 GERD 症状缓解率和 PPI 停药率高。在 SG 后 GERD 并发症的情况下,将其转为 RYGB 可改善术后结果,降低 GERD 症状并提高生活质量。