Viswanathan Sittarthan, Arumugam Thennavan, Sivaraj Rengaraj, Subhashri Rajendran Srihari, Ramesh Vimalavathini, Subramanian Kavimani, Vasanthi A Hannah Rachel
Department of Pharmacology, Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution), Puducherry - 605006, India.
Department of Pharmacology, Central Animal House, JIPMER, Puducherry - 605006.
Bioinformation. 2024 Apr 30;20(4):327-336. doi: 10.6026/973206300200327. eCollection 2024.
Sterubin (7-O-Methyleriodicytol), a flavanone compound isolated from the leaves of Eriodicyton californicum and Eriodicyton angustifolium, has neuroprotective, anti-inflammatory, and antioxidant properties. Therefore, it is of interest to identify the potential targets for Alzheimer disease using network pharmacology. We report 25 overlapping targets among 100 potential targets of sterubin and 673 known targets of Alzheimer. APP, BACE-1, and AChE were among the ten hub targets enriched in biological processes and pathways relevant to Alzheimer's disease. Subsequent, molecular docking analysis shows that sterubin have optimal binding features with these hub gene targets for further consideration.
斯德卢宾(7 - O - 甲基圣草酚)是一种从加州绵毛果和狭叶绵毛果的叶子中分离出来的黄烷酮化合物,具有神经保护、抗炎和抗氧化特性。因此,利用网络药理学确定阿尔茨海默病的潜在靶点具有重要意义。我们报告了斯德卢宾的100个潜在靶点与阿尔茨海默病的673个已知靶点中的25个重叠靶点。APP、BACE - 1和AChE是在与阿尔茨海默病相关的生物过程和通路中富集的十个枢纽靶点之一。随后,分子对接分析表明,斯德卢宾与这些枢纽基因靶点具有最佳结合特征,值得进一步研究。