六氟异丙醇促进的双官能化反应
Difunctionalization Processes Enabled by Hexafluoroisopropanol.
作者信息
Piejko Maciej, Moran Joseph, Lebœuf David
机构信息
Institut de Science et d'Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg, 8 Allée Gaspard Monge, 67000 Strasbourg, France.
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
出版信息
ACS Org Inorg Au. 2024 Mar 4;4(3):287-300. doi: 10.1021/acsorginorgau.3c00067. eCollection 2024 Jun 5.
In the past 5 years, hexafluoroisopropanol (HFIP) has been used as a unique solvent or additive to enable challenging transformations through substrate activation and stabilization of reactive intermediates. In this Review, we aim at describing difunctionalization processes which were unlocked when HFIP was involved. Specifically, we focus on cyclizations and additions to alkenes, alkynes, epoxides, and carbonyls that introduce a wide range of functional groups of interest.
在过去5年中，六氟异丙醇（HFIP）已被用作一种独特的溶剂或添加剂，通过底物活化和反应中间体的稳定化实现具有挑战性的转化。在本综述中，我们旨在描述涉及HFIP时开启的双官能化过程。具体而言，我们重点关注环化反应以及向烯烃、炔烃、环氧化物和羰基的加成反应，这些反应引入了一系列令人感兴趣的官能团。
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