Department of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras, Chennai, 600036, Tamilnadu, India.
Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, 695011, Kerala, India.
Med Biol Eng Comput. 2024 Nov;62(11):3411-3432. doi: 10.1007/s11517-024-03146-4. Epub 2024 Jun 10.
Aneurysms are bulges of an artery, which require clinical management solutions. Due to the inherent advantages, endovascular coil filling is emerging as the treatment of choice for intracranial aneurysms (IAs). However, after successful treatment of coil embolization, there is a serious risk of recurrence. It is well known that optimal packing density will enhance treatment outcomes. The main objective of endovascular coil embolization is to achieve flow stasis by enabling significant reduction in intra-aneurysmal flow and facilitate thrombus formation. The present study numerically investigates the effect of framing coil orientation on intra-aneurysmal hemodynamics. For the purpose of analysis, actual shape of the embolic coil is used, instead of simplified ideal coil shape. Typically used details of the framing coil are resolved for the analysis. However, region above the framing coil is assumed to be filled with a porous medium. Present simulations have shown that orientation of the framing coil loop (FCL) greatly influences the intra-aneurysmal hemodynamics. The FCLs which were placed parallel to the outlets of basilar tip aneurysm (Coil A) were found to reduce intra-aneurysmal flow velocity that facilitates thrombus formation. Involving the coil for the region is modeled using a porous medium model with a packing density of 20 . The simulations indicate that the framing coil loop (FCL) has a significant influence on the overall outcome.
动脉瘤是动脉的膨出,需要临床管理解决方案。由于其固有优势,血管内线圈填塞术正成为颅内动脉瘤(IA)的治疗选择。然而,在成功进行线圈栓塞治疗后,存在严重的复发风险。众所周知,最佳的填塞密度将提高治疗效果。血管内线圈栓塞的主要目的是通过显著减少瘤内血流并促进血栓形成来实现血流停滞。本研究通过数值方法研究了框架线圈方向对瘤内血液动力学的影响。为了进行分析,使用了实际的栓塞线圈形状,而不是简化的理想线圈形状。通常使用的框架线圈细节都被用于分析。然而,框架线圈上方的区域被假设为充满多孔介质。目前的模拟表明,框架线圈环(FCL)的方向极大地影响了瘤内血液动力学。放置在基底尖动脉瘤出口平行的 FCL(Coil A)被发现可以降低瘤内血流速度,从而促进血栓形成。使用填塞密度为 20 的多孔介质模型对涉及线圈的区域进行建模。模拟表明,框架线圈环(FCL)对整体结果有显著影响。