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人唾液黏蛋白 MUC7 片段及其 Cu(II)和 Zn(II)配合物的化学、结构和生物活性研究进展。

Insights into the Chemistry, Structure, and Biological Activity of Human Salivary MUC7 Fragments and Their Cu(II) and Zn(II) Complexes.

机构信息

Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.

Department of Biotechnology and Food Microbiology, Wrocław University of Environmental and Life Sciences, Chełmońskiego 37, 51-630 Wrocław, Poland.

出版信息

Inorg Chem. 2024 Jun 24;63(25):11616-11627. doi: 10.1021/acs.inorgchem.4c00868. Epub 2024 Jun 10.

DOI:10.1021/acs.inorgchem.4c00868
PMID:38856909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11200262/
Abstract

Mucin 7 (MUC7) is one of the salivary proteins whose role in the innate immune system is widely known, but still, neither its mechanism of action nor the impact of its metal coordination is fully understood. MUC7 and its fragments demonstrate potent antimicrobial activity, serving as a natural defense mechanism for organisms against pathogens. This study delves into the bioinorganic chemistry of MUC7 fragments (L1─EGRERDHELRHRRHHHQSPK; L2─EGRERDHELRHRR; L3─HHHQSPK) and their complexes with Cu(II) and Zn(II) ions. The antimicrobial characteristics of the investigated peptides and their complexes were systematically assessed against bacterial and fungal strains at pH 5.40 and pH 7.40. Our findings highlight the efficacy of these systems against , a common oral cavity pathogen. Most interestingly, Zn(II) coordination increased (or triggered) the MUC7 antimicrobial activity, which underscores the pivotal role of metal ion coordination in governing the antimicrobial activity of human salivary MUC7 fragments against .

摘要

黏蛋白 7（MUC7）是唾液蛋白之一，其在先天免疫系统中的作用广为人知，但它的作用机制及其金属配位的影响仍未完全被理解。MUC7 及其片段具有强大的抗菌活性，是生物体对抗病原体的天然防御机制。本研究深入探讨了 MUC7 片段（L1─EGRERDHELRHRRHHHQSPK；L2─EGRERDHELRHRR；L3─HHHQSPK）及其与 Cu(II)和 Zn(II)离子配合物的生物无机化学。在 pH 5.40 和 pH 7.40 下，系统评估了研究肽及其配合物对细菌和真菌菌株的抗菌特性。我们的研究结果突出了这些系统对 ，一种常见的口腔病原体的有效性。最有趣的是，Zn(II)配位增加（或触发）了 MUC7 的抗菌活性，这突显了金属离子配位在调节人唾液 MUC7 片段对 的抗菌活性方面的关键作用。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49a1/11200262/6e9121e66d4c/ic4c00868_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49a1/11200262/b24b73a5e624/ic4c00868_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49a1/11200262/b92cc91a8e0f/ic4c00868_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49a1/11200262/afeb3130d667/ic4c00868_0009.jpg
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