Ross D W
Arch Pathol Lab Med. 1985 Apr;109(4):309-13.
Leukemic blasts can be induced by external chemical agents to mature to neutrophils, monocytes, or RBCs. The phenotype of leukemic cells thus results from both internal genetic aberrations and the response of leukemic cells to their external environment. When human myeloid leukemia cells are exposed in vitro to a variety of agents (eg, vitamin A or dimethyl sulfoxide) the blasts lose their proliferative potential, the expression of oncogene products is sharply decreased, and after five days the leukemic cells become morphologically mature and functional neutrophils. Some patients with myeloid leukemias have responded to therapy designed to induce maturation in vivo. The induced maturation of leukemic cells is a new therapeutic tactic--an alternative to cytotoxic drug therapy--wherein leukemic cells are destroyed by transforming them into neutrophils.
白血病原始细胞可被外部化学物质诱导成熟为中性粒细胞、单核细胞或红细胞。白血病细胞的表型因此由内部遗传畸变以及白血病细胞对其外部环境的反应共同决定。当人类髓系白血病细胞在体外暴露于多种物质（如维生素A或二甲基亚砜）时，原始细胞失去其增殖潜能，癌基因产物的表达急剧下降，并且五天后白血病细胞在形态上成熟并成为有功能的中性粒细胞。一些髓系白血病患者对旨在诱导体内成熟的治疗有反应。白血病细胞的诱导成熟是一种新的治疗策略——细胞毒性药物治疗的替代方法——其中白血病细胞通过转化为中性粒细胞而被破坏。
