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用于检测膀胱浅表移行细胞癌中A、B和H血型同种抗原的单克隆抗体:一种预测侵袭性复发的方法。

Monoclonal antibodies to detect A, B and H blood group isoantigens in superficial transitional cell carcinoma of the bladder: a means of predicting invasive recurrences.

作者信息

Stephenson T J, Williams J L, Gelsthorpe K

出版信息

Br J Urol. 1985 Apr;57(2):148-53. doi: 10.1111/j.1464-410x.1985.tb06409.x.

Abstract

Monoclonal antibodies to A, B and H blood group isoantigens (BGI) have been used in an indirect immunoperoxidase technique to study the expression of BGI in both normal and malignant transitional epithelium in patients of all blood groups. BGI was detectable in all 15 biopsies of normal transitional epithelium and in 28 of 50 (56%) stage pTa and pTl transitional cell carcinomas of the bladder (TCCB). In the tumours failing to express BGI there was a 55% invasive recurrence rate at 5 years compared with 14% in those tumours expressing BGI. The difference was significant at the P less than 0.01 level. The recent availability of a monoclonal antibody to H isoantigen expressed in group O patients, in addition to monoclonal anti A and anti B, has made possible the inclusion of patients of all blood groups into a study using a standard immunoperoxidase technique without the need for specially processed biopsy material. The advantages of this technique compared with the earlier methods are discussed with reference to its possible role in identifying those patients at highest risk of developing invasive recurrence of their tumour.

摘要

针对A、B和H血型同种抗原(BGI)的单克隆抗体已被用于间接免疫过氧化物酶技术,以研究所有血型患者正常和恶性移行上皮中BGI的表达情况。在所有15例正常移行上皮活检样本以及50例膀胱移行细胞癌(TCCB)的pTa和pTl期肿瘤中的28例(56%)中均可检测到BGI。在未表达BGI的肿瘤中,5年侵袭性复发率为55%,而表达BGI的肿瘤为14%。差异在P小于0.01水平时具有显著性。除了单克隆抗A和抗B外,最近可获得针对O型血患者表达的H同种抗原的单克隆抗体,这使得所有血型的患者都能够纳入一项使用标准免疫过氧化物酶技术的研究,而无需特殊处理的活检材料。结合该技术在识别肿瘤侵袭性复发风险最高的患者方面可能发挥的作用,讨论了该技术与早期方法相比的优势。

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