Stroie Oana M., Vu Van H.
Walter Reed Military Medical Center
Louisiana State University Health Sciences Center, Shreveport, LA
Osteonecrosis is ischemia of bone due to inadequate vascular supply. This condition results in bone tissue death and loss of structural integrity. If left untreated, it can lead to bone collapse. This condition is also known as avascular necrosis or aseptic necrosis when it involves the epiphysis and as bone infarct when it involves metadiaphyseal regions of bone. Osteonecrosis is common and typically asymptomatic in its early stages. This condition affects various bones in the body, including hips, knees, shoulders, ankles, and small bones of hands and feet. Some of the most common causes of osteonecrosis include chronic corticosteroid use, alcohol use disorder, trauma, and idiopathic causes. Other common predispositions include systemic diseases such as sickle cell anemia and collagen vascular disease. Osteonecrosis may be asymptomatic in its early stage. This condition can also present with limited movement, inability to bear weight, significant pain, and swelling of the affected joint. Recognizing various presentations of osteonecrosis is crucial. In addition, understanding when and what further necessitates evaluation is important. When osteonecrosis involves the small bones of hands and feet or epiphysis of long bones, it is essential to assess the risk of secondary complications such as subchondral collapse. Imaging modalities used to evaluate osteonecrosis include plain radiographs, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine studies. However, knowing which modality is most sensitive at a certain point in the patient's clinical presentation and when it is necessary is crucial. Early diagnosis and treatment of osteonecrosis affecting epiphyseal locations remains the key to joint preservation.
骨坏死是由于血管供应不足导致的骨缺血。这种情况会导致骨组织死亡和结构完整性丧失。如果不进行治疗,可能会导致骨塌陷。当累及骨骺时,这种情况也被称为缺血性坏死或无菌性坏死;当累及骨干骺端区域时,则称为骨梗死。骨坏死很常见,早期通常无症状。这种情况会影响身体的各种骨骼,包括髋部、膝盖、肩部、脚踝以及手和脚的小骨头。骨坏死最常见的一些原因包括长期使用皮质类固醇、酒精使用障碍、创伤和特发性原因。其他常见的易患因素包括镰状细胞贫血和胶原血管病等全身性疾病。骨坏死在早期可能无症状。这种情况也可能表现为活动受限、无法负重、剧痛以及受累关节肿胀。认识到骨坏死的各种表现至关重要。此外,了解何时以及进一步需要评估什么也很重要。当骨坏死累及手和脚的小骨头或长骨的骨骺时,评估诸如软骨下塌陷等继发性并发症的风险至关重要。用于评估骨坏死的影像学检查方法包括X线平片、计算机断层扫描(CT)、磁共振成像(MRI)和核医学检查。然而,了解哪种检查方法在患者临床表现的某个阶段最敏感以及何时有必要进行检查至关重要。影响骨骺部位的骨坏死的早期诊断和治疗仍然是保留关节的关键。