Department of Stomatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Department of Stomatology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Arch Gerontol Geriatr. 2024 Oct;125:105522. doi: 10.1016/j.archger.2024.105522. Epub 2024 Jun 4.
Osteoarthritis (OA) is a prevalent chronic joint disease characterized by articular cartilage degeneration, pain, and disability. Emerging evidence indicates that mitochondrial quality control dysfunction contributes to OA pathogenesis. Mitochondria are essential organelles to generate cellular energy via oxidative phosphorylation and regulate vital processes. Impaired mitochondria can negatively impact cellular metabolism and result in the generation of harmful reactive oxygen species (ROS). Dysfunction in mitochondrial quality control mechanisms has been increasingly linked to OA onset and progression. This review summarizes current knowledge on the role of mitochondrial quality control disruption in OA, highlighting disturbed mitochondrial dynamics, impaired mitochondrial biogenesis, antioxidant defenses and mitophagy. The review also discusses potential therapeutic strategies targeting mitochondrial Quality Control in OA, offering future perspectives on advancing OA therapeutic strategies.
骨关节炎（OA）是一种常见的慢性关节疾病，其特征为关节软骨退化、疼痛和功能障碍。新出现的证据表明，线粒体质量控制功能障碍与 OA 的发病机制有关。线粒体是通过氧化磷酸化产生细胞能量并调节重要过程的必需细胞器。受损的线粒体可能会对细胞代谢产生负面影响，并导致有害的活性氧（ROS）的产生。线粒体质量控制机制的功能障碍与 OA 的发生和进展越来越相关。这篇综述总结了线粒体质量控制破坏在 OA 中的作用的现有知识，强调了线粒体动力学的紊乱、线粒体生物发生、抗氧化防御和线粒体自噬的受损。该综述还讨论了针对 OA 中线粒体质量控制的潜在治疗策略，为推进 OA 治疗策略提供了未来的展望。
