打破 CD8 T 细胞：调节性 T 细胞双人舞。
Breaking up the CD8 T cell: Treg pas de deux.
机构信息
Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
出版信息
Cancer Cell. 2024 Jun 10;42(6):941-942. doi: 10.1016/j.ccell.2024.05.016.
Checkpoint blockade immunotherapies, such as anti-programmed death-1 (PD-1), unleash anti-tumor CD8 T cell responses but may also induce immunosuppressive regulatory T cells (Tregs). In this issue of Cancer Cell, Geels et al. uncover that anti-PD-1 leads to Treg expansion via interleukin-2 (IL-2)-producing CD8 T cells. Combining anti-PD-1 with anti-ICOSL interrupts this crosstalk, thereby enhancing tumor control.
检查点阻断免疫疗法，如抗程序性死亡受体-1（PD-1），可以释放抗肿瘤 CD8 T 细胞反应，但也可能诱导免疫抑制调节性 T 细胞（Tregs）。在本期《癌细胞》中，Geels 等人发现抗 PD-1 通过产生白细胞介素 2（IL-2）的 CD8 T 细胞导致 Treg 扩增。将抗 PD-1 与抗 ICOS-L 联合使用可以阻断这种串扰，从而增强肿瘤控制。
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