Wagner G M, Schwartz R S, Chiu D T, Lubin B H
Clin Haematol. 1985 Feb;14(1):183-200.
This review has examined the lipid composition of the RBC membrane and the methods used to determine the distribution of the phospholipids within the membrane. The importance of the membrane cytoskeletal proteins, in particular spectrin and protein 4.1, in maintaining this distribution has also been described. Membrane vesiculation and altered membrane phospholipid asymmetry in sickle cell anaemia have been reviewed. The relationships between vesiculation and hypercoagulability and an abnormal reticuloendothelial system in sickle cell disease have been examined. It is apparent that the single amino acid substitution leading to the production of sickle haemoglobin has profound effects on the entire erythrocyte, reaching to the limits of the cell, its plasma membrane.
本综述研究了红细胞膜的脂质组成以及用于确定膜内磷脂分布的方法。还描述了膜细胞骨架蛋白，特别是血影蛋白和蛋白4.1，在维持这种分布中的重要性。对镰状细胞贫血中的膜泡化和膜磷脂不对称性改变进行了综述。研究了镰状细胞病中膜泡化与高凝性以及异常网状内皮系统之间的关系。显然，导致镰状血红蛋白产生的单个氨基酸取代对整个红细胞有深远影响，一直延伸到细胞及其质膜的极限。
