The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
School of Traditional Chinese Medicine Department, Beijing University of Chinese Medicine, Beijing, China.
Front Immunol. 2024 May 28;15:1374938. doi: 10.3389/fimmu.2024.1374938. eCollection 2024.
BACKGROUND: The effect of immune cells on autoimmune diseases (ADs) complicated by non-Hodgkin lymphoma (NHL) has been widely recognized, but a causal relationship between regulatory T cell (Treg) immune traits and ADs complicated by NHL remains debated. METHODS: Aggregate data for 84 Treg-related immune traits were downloaded from the Genome-Wide Association Study (GWAS) catalog, and GWAS data for diffuse large B-cell lymphoma (DLBCL; n=315243), follicular lymphoma (FL; n=325831), sjögren's syndrome (SS; n=402090), rheumatoid arthritis (RA; n=276465), dermatopolymyositis (DM; n=311640), psoriasis (n=407876), atopic dermatitis (AD; n=382254), ulcerative colitis (UC; n=411317), crohn's disease(CD; n=411973) and systemic lupus erythematosus (SLE; n=307587) were downloaded from the FinnGen database. The inverse variance weighting (IVW) method was mainly used to infer any causal association between Treg-related immune traits and DLBCL, FL, SS, DM, RA, Psoriasis, AD, UC, CD and SLE, supplemented by MR-Egger, weighted median, simple mode, and weighted mode. Moreover, we performed sensitivity analyses to assess the validity of the causal relationships. RESULTS: There was a potential genetic predisposition association identified between CD39+ CD8br AC, CD39+ CD8br % T cell, and the risk of DLBCL (OR=1.51, p<0.001; OR=1.25, p=0.001) (adjusted FDR<0.1). Genetic prediction revealed potential associations between CD25++ CD8br AC, CD28- CD25++ CD8br % T cell, CD39+ CD8br % CD8br, and the risk of FL (OR=1.13, p=0.022; OR=1.28, p=0.042; OR=0.90, p=0.016) (adjusted FDR>0.1). Furthermore, SLE and CD exhibited a genetically predicted potential association with the CD39+ CD8+ Tregs subset. SS and DM were possibly associated with an increase in the quantity of the CD4+ Tregs subset; RA may have reduced the quantity of the CD39+ CD8+ Tregs subset, although no causal relationship was identified. Sensitivity analyses supported the robustness of our findings. CONCLUSIONS: There existed a genetically predicted potential association between the CD39+ CD8+ Tregs subset and the risk of DLBCL, while SLE and CD were genetically predicted to be potentially associated with the CD39+ CD8+ Tregs subset. The CD39+ CD8+ Tregs subset potentially aided in the clinical diagnosis and treatment of SLE or CD complicated by DLBCL.
背景：免疫细胞对伴有非霍奇金淋巴瘤（NHL）的自身免疫疾病（AD）的影响已得到广泛认可，但调节性 T 细胞（Treg）免疫特征与伴有 NHL 的 AD 之间的因果关系仍存在争议。
方法：从全基因组关联研究（GWAS）目录中下载了 84 个与 Treg 相关的免疫特征的汇总数据，并从 FinnGen 数据库中下载了弥漫性大 B 细胞淋巴瘤（DLBCL；n=315243）、滤泡性淋巴瘤（FL；n=325831）、干燥综合征（SS；n=402090）、类风湿关节炎（RA；n=276465）、皮肌炎（DM；n=311640）、银屑病（n=407876）、特应性皮炎（AD；n=382254）、溃疡性结肠炎（UC；n=411317）、克罗恩病（CD；n=411973）和系统性红斑狼疮（SLE；n=307587）的 GWAS 数据。主要采用逆方差加权（IVW）法推断 Treg 相关免疫特征与 DLBCL、FL、SS、DM、RA、银屑病、AD、UC、CD 和 SLE 之间的任何因果关联，并通过 MR-Egger、加权中位数、简单模式和加权模式进行补充。此外，我们进行了敏感性分析，以评估因果关系的有效性。
结果：在 CD39+CD8brAC、CD39+CD8br%T 细胞与 DLBCL 风险之间发现了潜在的遗传易感性关联（OR=1.51，p<0.001；OR=1.25，p=0.001）（调整后的 FDR<0.1）。遗传预测显示 CD25++CD8brAC、CD28-CD25++CD8br%T 细胞、CD39+CD8br%CD8br 与 FL 风险之间存在潜在关联（OR=1.13，p=0.022；OR=1.28，p=0.042；OR=0.90，p=0.016）（调整后的 FDR>0.1）。此外，SLE 和 CD 与 CD39+CD8+Tregs 亚群的遗传预测具有潜在的关联。SS 和 DM 可能与 CD4+Tregs 亚群数量增加有关；RA 可能会减少 CD39+CD8+Tregs 亚群的数量，但没有发现因果关系。敏感性分析支持我们研究结果的稳健性。
结论：CD39+CD8+Tregs 亚群与 DLBCL 风险之间存在潜在的遗传预测关联，而 SLE 和 CD 可能与 CD39+CD8+Tregs 亚群存在潜在的遗传预测关联。CD39+CD8+Tregs 亚群可能有助于 SLE 或伴有 DLBCL 的 CD 的临床诊断和治疗。
Front Endocrinol (Lausanne). 2024
Medicine (Baltimore). 2024-6-28
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024-6-28
Front Psychiatry. 2024-5-16
Clin Rev Allergy Immunol. 2025-2-11
Front Immunol. 2023
touchREV Endocrinol. 2023-11
Nutrients. 2023-9-19
BMC Psychiatry. 2023-8-15
Biomark Res. 2023-6-7
Zotero 插件
