Balakirski Galina, Gäbelein-Wissing Noemi, Hofmann Silke C
Zentrum für Dermatologie, Allergologie und Dermatochirurgie, Helios Universitätsklinikum Wuppertal, Wuppertal, Deutschland.
Hautarztpraxis Dr. med. Rainer Schmidt & Dr. med. Noemi Gäbelein-Wissing, Wuppertal, Deutschland.
Dermatologie (Heidelb). 2024 Jul;75(7):518-527. doi: 10.1007/s00105-024-05368-x. Epub 2024 Jun 12.
Solar urticaria is a rare idiopathic photodermatosis. According to the current knowledge its pathogenesis is most likely based on an allergic type I reaction to an autoantigen activated by ultraviolet (UV) radiation or visible light. As many of the patients suffer from severe forms of the disease, it may therefore severely impair the quality of life of those affected. In contrast, polymorphous light eruption is a very common disease, which, according to the current data, can be interpreted as a type IV allergic reaction to a photoallergen induced by UV radiation. As the skin lesions heal despite continued sun exposure, the patients' quality of life is generally not significantly impaired. These two clinically and pathogenetically very different light dermatoses have shared diagnostics by means of light provocation and an important therapeutic option (light hardening). Herein, we present an overview of the clinical picture, pathogenesis, diagnosis and available treatment options for the above-mentioned diseases.
日光性荨麻疹是一种罕见的特发性光皮肤病。根据目前的认识，其发病机制很可能基于对由紫外线（UV）辐射或可见光激活的自身抗原的I型过敏反应。由于许多患者患有严重形式的该疾病，因此它可能会严重损害患者的生活质量。相比之下，多形性日光疹是一种非常常见的疾病，根据目前的数据，它可被解释为对UV辐射诱导的光变应原的IV型过敏反应。由于尽管持续暴露于阳光下皮肤病变仍会愈合，患者的生活质量通常不会受到明显损害。这两种在临床和发病机制上非常不同的光皮肤病通过光激发试验有共同的诊断方法以及一种重要的治疗选择（光致硬化）。在此，我们概述上述疾病的临床表现、发病机制、诊断和可用的治疗选择。
