探讨 RASGRP1 在疾病中的多方面作用：免疫、神经、代谢和致癌角度。
Exploring the multifaceted role of RASGRP1 in disease: immune, neural, metabolic, and oncogenic perspectives.
机构信息
The First Affiliated Hospital, Hunan Provincial Clinical Medical Research Center for Drug Evaluation of Major Chronic Diseases,Hengyang Medical School, University of South China, Hengyang, Hunan, China.
The First Affiliated Hospital, Hengyang Clinical Pharmacology Research Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
出版信息
Cell Cycle. 2024 Mar;23(6):722-746. doi: 10.1080/15384101.2024.2366009. Epub 2024 Jun 12.
RAS guanyl releasing protein 1 (RASGRP1) is a guanine nucleotide exchange factor (GEF) characterized by the presence of a RAS superfamily GEF domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating RAS through the exchange of bound GDP for GTP. Activation of RAS by RASGRP1 has a wide range of downstream effects at the cellular level. Thus, it is not surprising that many diseases are associated with RASGRP1 disorders. Here, we present an overview of the structure and function of RASGRP1, its crucial role in the development, expression, and regulation of immune cells, and its involvement in various signaling pathways. This review comprehensively explores the relationship between RASGRP1 and various diseases, elucidates the underlying molecular mechanisms of RASGRP1 in each disease, and identifies potential therapeutic targets. This study provides novel insights into the role of RASGRP1 in insulin secretion and highlights its potential as a therapeutic target for diabetes. The limitations and challenges associated with studying RASGRP1 in disease are also discussed.
RAS 鸟苷酸释放蛋白 1（RASGRP1）是一种鸟嘌呤核苷酸交换因子（GEF），其特征在于存在 RAS 超家族 GEF 结构域。它作为二酰基甘油（DAG）调节的核苷酸交换因子起作用，通过将结合的 GDP 交换为 GTP 来特异性地激活 RAS。RASGRP1 激活 RAS 在细胞水平上具有广泛的下游效应。因此，许多疾病与 RASGRP1 异常有关也就不足为奇了。在这里，我们概述了 RASGRP1 的结构和功能、它在免疫细胞的发育、表达和调节中的关键作用以及它在各种信号通路中的参与。本综述全面探讨了 RASGRP1 与各种疾病之间的关系，阐明了 RASGRP1 在每种疾病中的潜在分子机制，并确定了潜在的治疗靶点。这项研究深入了解了 RASGRP1 在胰岛素分泌中的作用，并强调了其作为糖尿病治疗靶点的潜力。还讨论了研究疾病中 RASGRP1 相关的局限性和挑战。
Zotero 插件