Advanced Radiation Oncology and Proton Therapy, Inova Health System, Fairfax, Virginia, USA.
RaySearch Laboratories, Stockholm, Sweden.
J Appl Clin Med Phys. 2024 Sep;25(9):e14374. doi: 10.1002/acm2.14374. Epub 2024 Jun 12.
Neurosurgical cranial titanium mesh and screws are commonly encountered in postoperative radiation therapy. However, only a limited number of reports are available in the context of proton therapy, resulting in a lack of consensus among the proton centers regarding the protocol for handling the hardware.
This study is to examine the impact of the hardware in proton plans. The results serve as evidence for proton centers to generate standard operating procedures to manage the hardware in proton treatment.
Plans with different gantry angles and material overrides are generated on the CT images of a phantom made of the hardware. The dose distributions of the plans with and without material override, at different depths are compared. Films and ionization chambers are used to measure the plans and the measurements are compared to the treatment planning system (TPS) calculations by gamma analysis.
There are some overdose and underdose regions downstream of the hardware. The overdose and underdose values are within a few percent of the prescribed dose when multiple fields with large hinge angles are used. The gamma analysis results show that the measurements agree with the TPS calculations within limits that are clinically relevant.
The study has demonstrated the influence of the hardware on proton plans. Based on the result of this study, a standard operating procedure of managing the hardware has been implemented in our clinic.
神经外科颅骨钛网和螺丝在术后放射治疗中很常见。然而,在质子治疗的背景下,仅有数量有限的报告可用,导致质子中心之间在处理硬件的协议方面缺乏共识。
本研究旨在检查硬件对质子计划的影响。研究结果为质子中心制定标准操作程序以管理质子治疗中的硬件提供了依据。
在包含硬件的体模的 CT 图像上生成具有不同旋转角度和材料覆盖的计划。比较具有和不具有材料覆盖的计划在不同深度的剂量分布。使用胶片和电离室测量计划,并通过伽马分析将测量值与治疗计划系统(TPS)计算值进行比较。
在硬件的下游存在一些超量和欠量区域。当使用具有大铰链角度的多个场时,超量和欠量值在规定剂量的几个百分点内。伽马分析结果表明,测量值与 TPS 计算值在临床相关的范围内一致。
本研究证明了硬件对质子计划的影响。基于这项研究的结果,我们的临床已经实施了管理硬件的标准操作程序。