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基于术前前列腺磁共振成像的单孔经膀胱机器人辅助根治性前列腺切除术后早期尿失禁的解剖学预测因素

Preoperative Prostate Magnetic Resonance Imaging-based Anatomical Predictors of Early Urinary Continence Following Single-port Transvesical Robot-assisted Radical Prostatectomy.

作者信息

Ramos Roxana, Shankar Prasad R, Soputro Nicolas A, Bullen Jennifer, Pedraza Adriana M, Chavali Jaya S, Mikesell Carter D, Ward Ryan, Purysko Andrei, Kaouk Jihad

机构信息

Urology Department, Cleveland Clinic, Cleveland, OH, USA.

Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.

出版信息

Eur Urol Focus. 2024 Dec;10(6):1027-1033. doi: 10.1016/j.euf.2024.05.025. Epub 2024 Jun 12.

Abstract

BACKGROUND AND OBJECTIVE

The introduction of the single-port (SP) robotic system has led to new approaches in robot-assisted radical prostatectomy (RARP), such as the transvesical (TV) approach, offering high rates of early urinary continence. While previous studies of SP TV RARP have identified perioperative factors influencing continence outcomes, the impact of anatomical factors remains unexplored. This study aims to assess magnetic resonance imaging (MRI)-based anatomical predictors of urinary continence after SP TV RARP.

METHODS

A retrospective analysis of consecutive SP TV RARP cases (November 2020 to June 2023) with preoperative prostate MRI was performed. Two urogenital radiologists independently evaluated ten anatomical parameters to distinguish patients achieving urinary continence within 1 wk and 3 mo. Nonparametric methods estimated receiver operating characteristic curves (area under the curve [AUC]) and inter-reader agreement.

KEY FINDINGS AND LIMITATIONS

In 120 cases, 40% achieved continence within 1 wk, rising to 71.7% by 3 mo. Membranous urethra length (MUL) alone was significantly associated with continence at 3 mo (AUC: 0.67, p = 0.003). At 1 wk, several parameters, including anteroposterior diameter of the prostate, coronal membranous urethra length, prostate volume, and transverse diameter of the prostate, showed promise in predicting continence.

CONCLUSIONS AND CLINICAL IMPLICATIONS

A longer preoperative MUL was significantly associated with better odds of an early return to urinary continence after SP TV RARP. Each 1-mm increase in coronal MUL was associated with a 27% increase in the odds of continence at 3 mo. This information can aid in patient counseling and expectations preoperatively.

PATIENT SUMMARY

Urinary incontinence is a common outcome after prostate cancer surgery, particularly in the early months. Recently, the single-port (SP) robotic system has emerged, localizing surgery to the diseased area. With the SP robot, accessing the prostate via the bladder leads to high rates of early continence. Our study reveals that the longer the urethral portion beneath the prostate, the higher the likelihood of regaining continence within 3 mo after surgery.

摘要

背景与目的

单孔(SP)机器人系统的引入为机器人辅助根治性前列腺切除术(RARP)带来了新方法,如经膀胱(TV)入路,其早期尿控率较高。虽然先前关于SP TV RARP的研究已确定了影响尿控结果的围手术期因素,但解剖学因素的影响仍未得到探索。本研究旨在评估基于磁共振成像(MRI)的SP TV RARP术后尿控的解剖学预测指标。

方法

对2020年11月至2023年6月连续进行的SP TV RARP病例且术前行前列腺MRI检查的患者进行回顾性分析。两名泌尿生殖系统放射科医生独立评估十个解剖学参数,以区分术后1周和3个月内实现尿控的患者。采用非参数方法估计受试者工作特征曲线(曲线下面积[AUC])及阅片者间一致性。

主要发现与局限性

在120例病例中,40%的患者在1周内实现尿控,到3个月时升至71.7%。仅膜性尿道长度(MUL)与3个月时的尿控显著相关(AUC:0.67,p = 0.003)。在1周时,包括前列腺前后径、冠状位膜性尿道长度、前列腺体积和前列腺横径在内的几个参数在预测尿控方面显示出前景。

结论与临床意义

术前MUL较长与SP TV RARP术后早期恢复尿控的更好几率显著相关。冠状位MUL每增加1毫米,3个月时尿控几率增加27%。这些信息有助于术前对患者进行咨询和设定预期。

患者总结

尿失禁是前列腺癌手术后常见的结果,尤其是在最初几个月。最近,单孔(SP)机器人系统出现,将手术定位到病变区域。使用SP机器人经膀胱进入前列腺可实现较高的早期尿控率。我们的研究表明,前列腺下方尿道部分越长,术后3个月内恢复尿控的可能性越高。

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