代谢手术对肝硬度影响的系统评价和荟萃分析。
Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness.
机构信息
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
出版信息
Rev Recent Clin Trials. 2024;19(4):236-241. doi: 10.2174/0115748871303052240529102003.
BACKGROUND
Bariatric surgery is one of the effective therapeutic options for people with obesity and obesity-related co-morbidities. In addition to weight-related co-morbid diseases, including diabetes, hypertension, and hypercholesterolemia, non-alcoholic fatty liver disease (NAFLD) is common in patients with morbid obesity. Bariatric surgery is one of the therapeutic options in the management of NAFLD. Hence, this review focused on the potential role of bariatric surgery on hepatic elasticity measured through shear wave elastography.
METHODS
A systematic literature search was performed, and the studies regarding heterogeneity were evaluated using the random-effects model.
RESULTS
The meta-analysis on 6 trials (3-12 months follow-up) including 350 participants showed a significant reduction of liver elasticity after surgery (WMD: -1.149, 95% CI: -1.767, -0.532, p < 0.001; I2:81.55%).
CONCLUSION
Bariatric surgery is associated with decreased liver elasticity. This improvement could be related to weight loss or other mechanisms of bariatric surgery.
背景
减重手术是肥胖症及其相关合并症患者的有效治疗选择之一。除了与体重相关的合并症（包括糖尿病、高血压和高胆固醇血症）外，非酒精性脂肪性肝病（NAFLD）在病态肥胖患者中也很常见。减重手术是治疗 NAFLD 的方法之一。因此，本综述重点关注通过剪切波弹性成像测量肝弹性的减重手术的潜在作用。
方法
进行了系统的文献检索，并使用随机效应模型评估了异质性研究。
结果
对 6 项试验（3-12 个月随访）共 350 名参与者的荟萃分析显示，手术后肝脏弹性显著降低（WMD：-1.149，95%CI：-1.767，-0.532，p < 0.001；I2：81.55%）。
结论
减重手术与肝脏弹性降低相关。这种改善可能与体重减轻或减重手术的其他机制有关。
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