QMD：一种量化组间微生物绝对丰度差异的新方法。

QMD: A new method to quantify microbial absolute abundance differences between groups.

作者信息

Mi Kai, Xu Yuyu, Li Yiqing, Liu Xingyin

机构信息

State Key Laboratory of Reproductive Medicine, Center of Global Health Nanjing Medical University Nanjing China.

Department of Pathogen Biology-Microbiology Division, Key Laboratory of Pathogen of Jiangsu Province Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical University Nanjing China.

出版信息

Imeta. 2023 Jan 5;2(1):e78. doi: 10.1002/imt2.78. eCollection 2023 Feb.

DOI:10.1002/imt2.78

PMID:38868342

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10989753/

Abstract

A new method, quantification of microbial absolute abundance differences (QMD), was proposed to estimate the microbial absolute abundance changes of each taxon under different conditions based on the microbial relative abundance. Compared with other methods, QMD displayed greater confidence in understanding microbiome dynamics between groups. We also provide QMD software to investigate common deviations and achieve a better understanding of microbiota changes under different conditions.

摘要

提出了一种新方法——微生物绝对丰度差异量化（QMD），用于基于微生物相对丰度估计不同条件下每个分类单元的微生物绝对丰度变化。与其他方法相比，QMD在理解组间微生物群动态方面表现出更高的可信度。我们还提供了QMD软件，以研究常见偏差，并更好地理解不同条件下微生物群的变化。