Shalash Ali, Doma Ahmed, Barakat Mai, Hamid Eman, Salama Mohamed
Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo 11757, Egypt.
Institute of Global Health and Human Ecology, The American University in Cairo, Cairo 11385, Egypt.
Biomed Rep. 2024 Jun 4;21(1):108. doi: 10.3892/br.2024.1796. eCollection 2024 Jul.
There is no definite biomarker for confirming the diagnosis of essential tremor (ET) or differentiating it from other diseases, particularly Parkinson's disease. The present study aimed to investigate the serum levels of the α-synuclein protein (α-syn) and its autoantibodies in patients with ET compared with healthy controls and its relation to motor and non-motor symptoms in patients with ET. Serum α-syn and its autoantibodies were measured in 32 patients with ET and 32 age- and sex-matched controls. Both groups were assessed using the non-motor symptoms scale, MoCA, Beck Depression Inventory, Hamilton Anxiety Rating Scale, and the Short Form 36 Health Survey Questionnaire. Tremor was assessed using the Fahn-Tolosa-Marin Tremor Rating Scale. The serum α-syn concentration in patients with ET was significantly lower than that in healthy controls (P<0.001), with a positive predictive value of 0.81 and a negative predictive value of 0.75, while the serum anti-a-syn autoantibody concentration was not significantly different between the two groups. There were no correlations between serum α-syn or its autoantibodies and patients' clinical characteristics. Furthermore, patients with ET had worse cognitive impairment, depression, anxiety, non-motor symptoms and quality of life. The serum α-syn concentration was lower in patients with ET than in controls, with favorable predictive values, suggesting that it could serve as a biomarker for ET diagnosis.
目前尚无确诊特发性震颤（ET）或鉴别其与其他疾病（尤其是帕金森病）的明确生物标志物。本研究旨在调查ET患者血清中α-突触核蛋白（α-syn）及其自身抗体水平，并与健康对照进行比较，同时研究其与ET患者运动和非运动症状的关系。对32例ET患者和32例年龄及性别匹配的对照者检测血清α-syn及其自身抗体。两组均使用非运动症状量表、蒙特利尔认知评估量表（MoCA）、贝克抑郁量表、汉密尔顿焦虑量表和健康调查简表36进行评估。使用法恩-托洛萨-马林震颤评定量表评估震颤情况。ET患者血清α-syn浓度显著低于健康对照者（P<0.001），阳性预测值为0.81，阴性预测值为0.75，而两组血清抗α-syn自身抗体浓度无显著差异。血清α-syn及其自身抗体与患者临床特征之间无相关性。此外，ET患者存在更严重的认知障碍、抑郁、焦虑、非运动症状和生活质量问题。ET患者血清α-syn浓度低于对照者，且具有良好的预测价值，提示其可作为ET诊断的生物标志物。
