Terz J J, Beatty J D
Surg Annu. 1979;11:149-80.
Less than 40 percent of all carcinomas of the gastrointestinal tract will be controlled by the current modalities of treatment. Early diagnosis and appropriate surgical resection are still the only rational and effective approach to the control of this cancer. The tremendous strides in cancer chemotherapy in the management of leukemia, children's solid tumors, and neoplasms of lymphoid origin have not been evident in the management of gastrointestinal carcinoma. Extensive clinical trials with single agents and various drug combinations have resulted so far in partial response rates. Adjuvant chemotherapy to surgical resection has also failed to alter the natural course of the disease and, therefore, to establish its benefits in a series of projective randomized studies. Only continued research in cancer cell biology and basic and clinical pharmacology with carefully controlled therapeutic trials with new agents will eventually lead to the more effective use of chemotherapy in management of gastrointesinal cancer.
目前的治疗方式仅能控制不到40%的胃肠道癌。早期诊断和恰当的手术切除仍是控制这种癌症唯一合理且有效的方法。癌症化疗在白血病、儿童实体瘤及淋巴源性肿瘤的治疗中取得了巨大进展，但在胃肠道癌的治疗中却未体现出来。迄今为止，针对单一药物及各种联合用药方案开展的大量临床试验仅取得了部分缓解率。辅助化疗未能改变疾病的自然进程，因此，在一系列前瞻性随机研究中也未能证实其益处。只有持续开展癌细胞生物学、基础与临床药理学研究，并精心控制新药的治疗试验，最终才能在胃肠道癌的治疗中更有效地运用化疗。
