Lenarz T
Laryngol Rhinol Otol (Stuttg). 1985 Mar;64(3):158-61.
The treatment of tinnitus patients is a major problem in ENT. This depends on the fact that no objective parameter exists for this symptom. Therefore, every treatment schedule should meet the criteria of a rational tinnitus treatment. The value of lidocaine in the management of the tinnitus patient was assessed in a randomised blind-controlled cross-over trial. 20 patients with sensorineural hearing loss of different kinds and a well defined tinnitus were treated by an intravenous infusion of lidocaine. 13 patients reported a tinnitus suppression of more than 50 per cent, whereas there was no response with saline. These subjective changes were accompanied by BERA alterations such as a reversible lengthening of central conduction time without hearing impairment. The mechanism of action of lidocaine in tinnitus is discussed according to electrophysiological hypotheses.
耳鸣患者的治疗是耳鼻喉科的一个主要问题。这取决于该症状不存在客观参数这一事实。因此，每个治疗方案都应符合合理耳鸣治疗的标准。在一项随机双盲对照交叉试验中评估了利多卡因在耳鸣患者治疗中的价值。20例患有不同类型感音神经性听力损失且耳鸣明确的患者接受了静脉注射利多卡因治疗。13例患者报告耳鸣抑制超过50%，而注射生理盐水时则无反应。这些主观变化伴随着脑干听觉诱发电位（BERA）的改变，如中枢传导时间可逆性延长且无听力损害。根据电生理假说讨论了利多卡因治疗耳鸣的作用机制。
