生物钟基因 CLOCK 在癌症中的作用。

The role of circadian gene CLOCK in cancer.

机构信息

Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China; NHC Key Laboratory of Carcinogenesis, the Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China.

Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China; Department of Pathology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China.

出版信息

Biochim Biophys Acta Mol Cell Res. 2024 Oct;1871(7):119782. doi: 10.1016/j.bbamcr.2024.119782. Epub 2024 Jun 12.

DOI:10.1016/j.bbamcr.2024.119782

PMID:38871225

Abstract

Circadian Locomotor Output Cycles Kaput (CLOCK) is one of the circadian clock genes and is considered to be a fundamental regulatory gene in the circadian rhythm, responsible for mediating several biological processes. Therefore, abnormal expression of CLOCK affects its role in the circadian clock and its more general function as a direct regulator of gene expression. This dysfunction can lead to severe pathological effects, including cancer. To better understand the role of CLOCK in cancer, we compiled this review to describe the biological function of CLOCK, and especially highlighted its function in cancer development, progression, tumor microenvironment, cancer cell metabolism, and drug resistance.

摘要

生物钟输出周期关键基因（Circadian Locomotor Output Cycles Kaput，CLOCK）是生物钟基因之一，被认为是生物钟节律的基本调节基因，负责介导多种生物学过程。因此，CLOCK 的异常表达会影响其在生物钟中的作用及其作为基因表达直接调节剂的更普遍功能。这种功能障碍可能导致严重的病理效应，包括癌症。为了更好地理解 CLOCK 在癌症中的作用，我们编写了这篇综述，描述了 CLOCK 的生物学功能，特别强调了它在癌症发展、进展、肿瘤微环境、癌细胞代谢和耐药性中的作用。