Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No.3 East Qingchun Road, Jianggan District, Hangzhou 310016, China.
Department of Anesthesiology, Second Affiliated Hospital of Jiaxing University, No.1518 North Huancheng Road, Nanhu District, Jiaxing 314000, China.
Mitochondrion. 2024 Sep;78:101920. doi: 10.1016/j.mito.2024.101920. Epub 2024 Jun 12.
Mitochondria orchestrate the production of new mitochondria and the removal of damaged ones to dynamically maintain mitochondrial homeostasis through constant biogenesis and clearance mechanisms. Mitochondrial quality control particularly relies on mitophagy, defined as selective autophagy with mitochondria-targeting specificity. Most ROS are derived from mitochondria, and the physiological concentration of mitochondrial ROS (mtROS) is no longer considered a useless by-product, as it has been proven to participate in immune and autophagy pathway regulation. However, excessive mtROS appears to be a pathogenic factor in several diseases, including acute lung injury (ALI). The interplay between mitophagy and mtROS is complex and closely related to ALI. Here, we review the pathways of mitophagy, the intricate relationship between mitophagy and mtROS, the role of mtROS in the pathogenesis of ALI, and their effects and related progression in ALI induced by different conditions.
线粒体通过不断的生物发生和清除机制，协调新线粒体的产生和受损线粒体的清除，从而动态维持线粒体的稳态。线粒体质量控制特别依赖于自噬体选择性吞噬具有线粒体靶向特异性的线粒体，即自噬体选择性吞噬线粒体。大多数 ROS 来自线粒体，生理浓度的线粒体 ROS（mtROS）不再被认为是无用的副产物，因为它已被证明参与免疫和自噬途径的调节。然而，过量的 mtROS 似乎是几种疾病（包括急性肺损伤）的致病因素。自噬体选择性吞噬线粒体和 mtROS 之间的相互作用非常复杂，与急性肺损伤密切相关。在这里，我们综述了自噬体选择性吞噬线粒体的途径、自噬体选择性吞噬线粒体与 mtROS 之间的复杂关系、mtROS 在急性肺损伤发病机制中的作用，以及它们在不同条件诱导的急性肺损伤中的作用和相关进展。
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