WhiB 样蛋白：结构、功能和机制的多样性。
WhiB-like proteins: Diversity of structure, function and mechanism.
机构信息
Department of Biochemistry, University of Nebraska-Lincoln, N138 Beadle Center, 1901 Vine Street, Lincoln, NE 68588, USA.
Department of Biochemistry, University of Nebraska-Lincoln, N138 Beadle Center, 1901 Vine Street, Lincoln, NE 68588, USA; Redox Biology Center, University of Nebraska-Lincoln, N138 Beadle Center, 1901 Vine Street, Lincoln, NE 68588, USA; Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, N138 Beadle Center, 1901 Vine Street, Lincoln, NE 68588, USA.
出版信息
Biochim Biophys Acta Mol Cell Res. 2024 Oct;1871(7):119787. doi: 10.1016/j.bbamcr.2024.119787. Epub 2024 Jun 13.
The WhiB-Like (Wbl) proteins are a large family of iron-sulfur (Fe-S) cluster-containing transcription factors exclusively found in the phylum Actinobacteria, including the notable genera like Mycobacteria, Streptomycetes and Corynebacteria. These proteins play pivotal roles in diverse biological processes, such as cell development, redox stress response and antibiotic resistance. Members of the Wbl family exhibit remarkable diversity in their sequences, structures and functions, attracting great attention since their first discovery. This review highlights the most recent breakthroughs in understanding the structural and mechanistic aspects of Wbl-dependent transcriptional regulation.
WhiB 样（Wbl）蛋白是一个大型的铁硫（Fe-S）簇转录因子家族，仅存在于放线菌门，包括分枝杆菌属、链霉菌属和棒状杆菌属等著名属。这些蛋白在多种生物学过程中发挥关键作用，如细胞发育、氧化还原应激反应和抗生素耐药性。Wbl 家族成员在序列、结构和功能上表现出显著的多样性，自首次发现以来引起了广泛关注。本文综述了近年来在理解 Wbl 依赖性转录调控的结构和机制方面的最新突破。
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