Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
BMC Ophthalmol. 2024 Jun 17;24(1):260. doi: 10.1186/s12886-024-03481-y.
Quantitative analysis of retinal nerve fibers is important for the diagnosis and treatment of optic nerve diseases. Peripapillary retinal nerve fiber layer (RNFL) cross-sectional area may give a more accurate quantitative assessment of retinal nerve fibers than RNFL thickness but there have been no previous reports of the peripapillary RNFL cross-sectional area or other parameters. The purpose of the current study was to determine peripapillary RNFL cross-sectional area and its association with other factors in an adult Chinese population.
RNFL cross-sectional area was measured during peripapillary circular optical coherence tomography (OCT) scan with a diameter of 12° centered on the optic disc. Correlation between RNFL cross-sectional area and other parameters was evaluated by linear regression analysis in a cross-sectional study of an adult Chinese population.
A total of 2404 eyes from 2404 subjects were examined. Multivariate linear regression analysis showed that larger RNFL cross-sectional area correlated with younger age (p < 0.001), female gender (p = 0.001), no history of diabetes (p = 0.012) and larger optic disc area (p < 0.001).
Peripapillary RNFL cross-sectional area is correlated positively with optic disc area, suggesting that eyes with larger optic discs have thicker RNFL. Further studies are needed to confirm whether this correlation is due to differences in the numbers of retinal nerve fibers or other factors.
视网膜神经纤维的定量分析对于视神经疾病的诊断和治疗非常重要。与视网膜神经纤维层（RNFL）厚度相比，视盘周围 RNFL 横截面积可能对视网膜神经纤维提供更准确的定量评估，但目前尚无视盘周围 RNFL 横截面积或其他参数的相关报道。本研究旨在确定成人中国人群的视盘周围 RNFL 横截面积及其与其他因素的关系。
使用直径为 12°的视盘周围环形光相干断层扫描（OCT）测量 RNFL 横截面积，以视盘为中心。在一项成人中国人群的横断面研究中，通过线性回归分析评估 RNFL 横截面积与其他参数之间的相关性。
共检查了 2404 名受试者的 2404 只眼。多变量线性回归分析表明，较大的 RNFL 横截面积与较年轻的年龄（p<0.001）、女性（p=0.001）、无糖尿病史（p=0.012）和较大的视盘面积（p<0.001）相关。
视盘周围 RNFL 横截面积与视盘面积呈正相关，表明视盘较大的眼睛具有较厚的 RNFL。需要进一步的研究来证实这种相关性是由于视网膜神经纤维数量的差异还是其他因素所致。
