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精神分裂症患者大脑皮质形态测量相似性网络的拓扑异常

Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia.

作者信息

Joo Sung Woo, Jo Young Tak, Choi Woohyeok, Kim Sun Min, Yoo So Young, Joe Soohyun, Lee Jungsun

机构信息

Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Department of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.

出版信息

Schizophrenia (Heidelb). 2024 Jun 17;10(1):57. doi: 10.1038/s41537-024-00477-x.

Abstract

A morphometric similarity (MS) network can be constructed using multiple magnetic resonance imaging parameters of each cortical region. An MS network can be used to assess the similarity between cortical regions. Although MS networks can detect microstructural alterations and capture connections between histologically similar cortical areas, the influence of schizophrenia on the topological characteristics of MS networks remains unclear. We obtained T1- and diffusion-weighted images of 239 healthy controls and 190 individuals with schizophrenia to construct the MS network. Group comparisons of the mean MS of the cortical regions and subnetworks were performed. The strengths of the connections between the cortical regions and the global and nodal network indices were compared between the groups. Clinical associations with the network indices were tested using Spearman's rho. Compared with healthy controls, individuals with schizophrenia had significant group differences in the mean MS of several cortical regions and subnetworks. Individuals with schizophrenia had both superior and inferior strengths of connections between cortical regions compared with those of healthy controls. We observed regional abnormalities of the MS network in individuals with schizophrenia regarding lower centrality values of the pars opercularis, superior frontal, and superior temporal areas. Specific nodal network measures of the right pars opercularis and left superior temporal areas were associated with illness duration in individuals with schizophrenia. We identified regional abnormalities of the MS network in schizophrenia with the left superior temporal area possibly being a key region in topological organization and cortical connections.

摘要

可以使用每个皮质区域的多个磁共振成像参数构建形态计量相似性(MS)网络。MS网络可用于评估皮质区域之间的相似性。尽管MS网络能够检测微观结构改变并捕捉组织学上相似的皮质区域之间的连接,但精神分裂症对MS网络拓扑特征的影响仍不清楚。我们获取了239名健康对照者和190名精神分裂症患者的T1加权图像和扩散加权图像,以构建MS网络。对皮质区域和子网络的平均MS进行了组间比较。比较了两组之间皮质区域与全局和节点网络指标之间连接的强度。使用斯皮尔曼等级相关系数检验了与网络指标的临床关联。与健康对照者相比,精神分裂症患者在几个皮质区域和子网络的平均MS方面存在显著的组间差异。与健康对照者相比,精神分裂症患者皮质区域之间连接的强度既有增强也有减弱。我们观察到精神分裂症患者的MS网络存在区域异常,表现为岛盖部、额上回和颞上回区域的中心性值较低。右岛盖部和左颞上回区域的特定节点网络指标与精神分裂症患者的病程相关。我们确定了精神分裂症患者MS网络的区域异常,其中左颞上回区域可能是拓扑组织和皮质连接中的关键区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb3/11183129/a2078c74c622/41537_2024_477_Fig1_HTML.jpg

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