头孢洛林用于中枢神经系统和眼部感染：病例系列
Ceftaroline in CNS and ocular infections: a case series.
作者信息
Siegrist Emily A, Sassine Joseph
机构信息
Department of Pharmacy, OU Health, OU Medical Center, 700 NE 13th St., Oklahoma City, OK 73104, USA.
Infectious Diseases Section, Department of Medicine, The University of Oklahoma Health Sciences Center, 800 Stanton L. Young Blvd, Oklahoma City, OK 73104, USA.
出版信息
JAC Antimicrob Resist. 2024 Jun 17;6(3):dlae095. doi: 10.1093/jacamr/dlae095. eCollection 2024 Jun.
BACKGROUND
There are limited data describing outcomes of patients treated with ceftaroline for infections with CNS or ocular involvement.
OBJECTIVES
To describe outcomes of patients treated with ceftaroline for methicillin-resistant staphylococcal infections involving the CNS or eye.
PATIENTS AND METHODS
This was a retrospective review of 10 patients at an academic medical centre who received ceftaroline for CNS or ocular infections.
RESULTS
All patients were treated with ceftaroline as part of a combination for salvage therapy. Four patients died, whereas six patients experienced clinical cure. Only one experienced microbiological recurrence.
CONCLUSIONS
These preliminary data suggest that ceftaroline may be an option for salvage therapy of severe staphylococcal infections when used in combination.
背景
关于使用头孢洛林治疗中枢神经系统（CNS）或眼部感染患者的疗效数据有限。
目的
描述使用头孢洛林治疗耐甲氧西林葡萄球菌引起的中枢神经系统或眼部感染患者的疗效。
患者与方法
这是一项对某学术医疗中心10例接受头孢洛林治疗中枢神经系统或眼部感染患者的回顾性研究。
结果
所有患者均接受头孢洛林治疗，作为挽救治疗联合方案的一部分。4例患者死亡，6例患者实现临床治愈。仅1例出现微生物学复发。
结论
这些初步数据表明，联合使用时，头孢洛林可能是严重葡萄球菌感染挽救治疗的一种选择。
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