Slaight Family Centre for Youth in Transition, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
JAMA Psychiatry. 2024 Sep 1;81(9):928-935. doi: 10.1001/jamapsychiatry.2024.1467.
Characterizing mental health service use trajectories preceding diagnosis of a psychotic disorder may help identify individuals at highest risk and in which settings they are at highest risk.
To examine mental health service use and diagnostic trajectories before first diagnosis of psychotic disorder and identify utilization and diagnostic patterns.
DESIGN, SETTING, AND PARTICIPANTS: This population-based, retrospective cohort study used linked provincial health administrative data. The sample included individuals aged 15 to 29 years diagnosed with a psychotic disorder in Ontario, Canada, between April 1, 2012, and March 31, 2018. These individuals were matched to individuals with a diagnosis of a mood disorder. Data were analyzed from November 2018 to November 2019.
The main outcomes were rates, timing, and setting of mental health-related service use and associated diagnoses in the 3 years before the index disorder among individuals first diagnosed with a psychotic disorder compared with those first diagnosed with a mood disorder.
A total of 10 501 individuals with a first diagnosis of psychotic disorder were identified (mean [SD] age, 21.55 [3.83] years; 72.1% male). A total of 72.2% of individuals had at least 1 mental health service visit during the 3 years before their first psychotic disorder diagnosis, which was significantly more than matched controls with a first mood disorder diagnosis (66.8%) (odds ratio [OR], 1.34; 95% CI, 1.26-1.42). Compared with individuals diagnosed with a mood disorder, individuals diagnosed with a psychotic disorder were significantly more likely to have had mental health-related hospital admissions (OR, 3.98; 95% CI, 3.43-4.62) and emergency department visits (OR, 2.27; 95% CI, 2.12-2.43) in the preceding 3 years. Those with psychotic disorders were more likely to have had prior diagnoses of substance use disorders (OR, 2.57; 95% CI, 2.35-2.81), other disorders (personality disorders, developmental disorders) (OR, 1.75; 95% CI, 1.61-1.90), and self-harm (OR, 1.64; 95% CI, 1.36-1.98) in the past 3 years compared with those diagnosed with mood disorders.
This study found that in the 3 years prior to an index diagnosis, individuals with a first diagnosis of psychotic disorder had higher rates of mental health service use, particularly emergency department visits and hospitalizations, compared with individuals with a first diagnosis of a mood disorder. Individuals with psychotic disorders also had a greater number of premorbid diagnoses. Differences in health service utilization patterns between those with a first psychotic disorder diagnosis vs a first mood disorder diagnosis suggest distinct premorbid trajectories that could be useful for next steps in prediction and prevention research.
在精神障碍诊断前描述心理健康服务使用轨迹,可能有助于确定风险最高的个体以及他们在哪些环境中风险最高。
检查首次诊断为精神障碍前的心理健康服务使用和诊断轨迹,并确定利用和诊断模式。
设计、设置和参与者:这是一项基于人群的回顾性队列研究,使用了省级卫生行政数据。该样本包括在加拿大安大略省,2012 年 4 月 1 日至 2018 年 3 月 31 日期间首次被诊断为精神障碍的年龄在 15 至 29 岁的个体。这些个体与首次被诊断为心境障碍的个体相匹配。数据于 2018 年 11 月至 2019 年 11 月进行分析。
主要结果是与首次被诊断为心境障碍的个体相比,首次被诊断为精神障碍的个体在疾病前 3 年内心理健康相关服务的使用频率、时间和地点,以及相关诊断。
共确定了 10501 名首次被诊断为精神障碍的个体(平均[SD]年龄,21.55[3.83]岁;72.1%为男性)。在疾病前 3 年内,至少有 1 次心理健康服务就诊的个体占 72.2%,明显高于首次被诊断为心境障碍的匹配对照组(66.8%)(比值比[OR],1.34;95%CI,1.26-1.42)。与被诊断为心境障碍的个体相比,被诊断为精神障碍的个体在前 3 年内更有可能有心理健康相关的住院治疗(OR,3.98;95%CI,3.43-4.62)和急诊就诊(OR,2.27;95%CI,2.12-2.43)。精神障碍患者更有可能在过去 3 年内有物质使用障碍(OR,2.57;95%CI,2.35-2.81)、其他障碍(人格障碍、发育障碍)(OR,1.75;95%CI,1.61-1.90)和自伤(OR,1.64;95%CI,1.36-1.98)的诊断,而心境障碍患者则较少有这些诊断。
这项研究发现,在指数诊断前的 3 年内,首次被诊断为精神障碍的个体与首次被诊断为心境障碍的个体相比,心理健康服务的使用率更高,尤其是急诊就诊和住院治疗。精神障碍患者也有更多的前期诊断。首次被诊断为精神障碍与首次被诊断为心境障碍的个体在卫生服务利用模式上的差异表明存在不同的前期轨迹,这可能对预测和预防研究的下一步有帮助。