One of these strains is not like the others: DW102 has an altered dependence on and for regulation of gene transcription.

Several strains of with mutations in or are readily available to aid in elucidating the functions of these two genes in DNA damage repair, meiosis, and gene repression. DW102 is the only strain to our knowledge with mutations in both and . However, several groups have reported the DW102 strain is indistinguishable from wild-type when observing levels of embryonic lethality, sensitivity to radiation, and rates of male progeny, while strains with mutations in either or display increased occurrence of these phenotypes. Here, RT-qPCR analysis of the gene family, reveals distinctive and aberrant expression patterns in DW102 compared to other or mutant strains underscoring the need for caution in choosing this strain to draw conclusions about and functions.