Wang Yingyi, Hao Yanwei, Yuan Lingling, Tian Huaie, Sun Xuhui, Zhang Yi
Department of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2024 Jun 4;15:1379058. doi: 10.3389/fphar.2024.1379058. eCollection 2024.
Ulcerative colitis (UC), a subtype of inflammatory bowel disease, manifests with symptoms such as abdominal pain, diarrhea, and mucopurulent, bloody stools. The pathogenesis of UC is not fully understood. At present, the incidence of UC has increased significantly around the world. Conventional therapeutic arsenals are relatively limited, with often poor efficacy and many adverse effects. In contrast, traditional Chinese medicine (TCM) holds promise due to their notable effectiveness, reduced recurrence rates, and minimal side effects. In recent years, significant progress has been made in the basic research on TCM for UC treatment. It has been found that the inhibition of ferroptosis through the intervention of TCM can significantly promote intestinal mucosal healing and reverse UC. The mechanism of action involves multiple targets and pathways.
This review summarizes the experimental studies on the targeted regulation of ferroptosis by TCM and its impact on UC in recent years, aiming to provide theoretical basis for the prevention, treatment, and further drug development for UC.
Ferroptosis disrupts antioxidant mechanisms in intestinal epithelial cells, damages the intestinal mucosa, and participates in the pathological process of UC. TCM acts on various pathways such as / and GSH/GPX4, blocking the pathological progression of ferroptosis in intestinal epithelial cells, inhibiting pathological damage to the intestinal mucosa, and thereby alleviating UC.
The diverse array of TCM single herbs, extracts and herbal formulas facilitates selective and innovative research and development of new TCM methods for targeting UC treatment. Although progress has been made in studying TCM compound formulas, single herbs, and extracts, there are still many issues in clinical and basic experimental designs, necessitating further in-depth scientific exploration and research.
溃疡性结肠炎（UC）是炎症性肠病的一种亚型，表现为腹痛、腹泻以及黏液脓性血便等症状。UC的发病机制尚未完全明确。目前，UC在全球的发病率显著上升。传统治疗手段相对有限，疗效往往不佳且不良反应众多。相比之下，中医药因其显著疗效、较低的复发率和最小的副作用而颇具前景。近年来，中医药治疗UC的基础研究取得了显著进展。研究发现，通过中医药干预抑制铁死亡可显著促进肠黏膜愈合并逆转UC。其作用机制涉及多个靶点和途径。
本综述总结近年来中医药对铁死亡靶向调控及其对UC影响的实验研究，旨在为UC的预防、治疗及进一步的药物研发提供理论依据。
铁死亡破坏肠上皮细胞的抗氧化机制，损伤肠黏膜，参与UC的病理过程。中医药作用于如/和谷胱甘肽/谷胱甘肽过氧化物酶4等多种途径，阻断肠上皮细胞铁死亡的病理进程，抑制肠黏膜的病理损伤，从而缓解UC。
种类繁多的中药单味药、提取物及中药复方有利于针对UC治疗的新型中医药方法进行选择性和创新性研发。尽管在研究中药复方、单味药及提取物方面已取得进展，但临床和基础实验设计仍存在诸多问题，需要进一步深入的科学探索与研究。
