[癌胚抗原在胃癌和结直肠癌中的意义]

[Significance of CEA in gastric and colorectal cancer].

作者信息

Uehara K, Miyamoto Y, Izuo M, Shiozaki H, Aiba S, Matsumoto H

出版信息

Nihon Geka Gakkai Zasshi. 1985 Apr;86(4):435-42.

Abstract

The determination of serum CEA (Sandwich method) and CEA staining (PAP method) of excised specimens were performed in patients with gastric or colorectal cancer, and the biological characteristics of each cancer and the factors to increase serum CEA were studied with the following results: As colonic cancer has strong CEA productivity, serum CEA can be useful for the detection of cancer, and especially effective for the postoperative observation. Gastric cancer has weak CEA productivity, and serum CEA is not so useful in the detection of cancer and the judgement of resectability. The CEA positive rate of tissue with CEA staining was 80% in gastric cancer, 100% in colonic cancer, and were nearly equal to the CEA positive rate of serum in the group of terminal stage. In the mode of CEA staining of cancerous cells, IV type was observed most frequently in gastric cancer, and I type in colonic cancer. Among the resected cases showing more than 7ng/ml serum CEA, differentiated type, lymph node metastasis (+), the degree of tissue staining with CEA staining, the mode of cell staining O or I type in gastric cancer and I type in colonic cancer were observed in common.

摘要

对胃癌或结直肠癌患者进行血清癌胚抗原（夹心酶标法）测定及切除标本的癌胚抗原染色（PAP法），并研究了各癌症的生物学特性及血清癌胚抗原升高的因素，结果如下：由于结肠癌产生癌胚抗原的能力较强，血清癌胚抗原可用于癌症检测，尤其对术后观察有效。胃癌产生癌胚抗原的能力较弱，血清癌胚抗原在癌症检测及可切除性判断方面不太有用。癌胚抗原染色组织的癌胚抗原阳性率在胃癌中为80%，在结肠癌中为100%，且与晚期组血清癌胚抗原阳性率几乎相等。在癌细胞的癌胚抗原染色模式中，IV型在胃癌中最常见，I型在结肠癌中最常见。在血清癌胚抗原超过7ng/ml的切除病例中，常见的有分化型、淋巴结转移（+）、癌胚抗原染色的组织染色程度、胃癌中细胞染色模式为O或I型以及结肠癌中为I型。