The First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, Hefei, Anhui 230000, China; Anhui No.2 Provincial People's Hospital, Department of Endocrinology, Hefei, Anhui 230000, China.
Anhui Medical College, Department of Clinical Medicine, Hefei, Anhui 230000, China.
Exp Gerontol. 2024 Sep;194:112496. doi: 10.1016/j.exger.2024.112496. Epub 2024 Jun 25.
Osteoporosis is linked to impaired function of osteoblasts, and decreased expression of METTL14 may result in abnormal differentiation of these bone-forming cells. However, the specific impact of METTL14 on osteoblast differentiation and its underlying mechanisms are not yet fully understood.
This study discovered a positive correlation between METTL14 expression and bone formation in specimens from osteoporosis patients and ovariectomized (OVX) mice. Additionally, METTL14 targeting of SLC25A3 contributed to the restoration of mitochondrial ROS levels and mitochondrial membrane potential in osteoblasts and promoted osteoblast differentiation. Moreover, in vivo experiments showed that METTL14 enhanced bone formation, and therapeutic introduction of METTL14 countered the decrease in bone formation in OVX mice.
Overall, these findings emphasize the crucial role of the METTL14/SLC25A3 signaling axis in osteoblast activity, suggesting that this axis could be a potential target for improving osteoporosis.
骨质疏松症与成骨细胞功能受损有关，而 METTL14 表达的降低可能导致这些成骨细胞的异常分化。然而，METTL14 对成骨细胞分化的具体影响及其潜在机制尚不完全清楚。
本研究发现 METTL14 表达与骨质疏松症患者和去卵巢（OVX）小鼠标本中的骨形成呈正相关。此外，METTL14 靶向 SLC25A3 有助于恢复成骨细胞中的线粒体 ROS 水平和线粒体膜电位，并促进成骨细胞分化。此外，体内实验表明 METTL14 增强了骨形成，并且 METTL14 的治疗性引入可以对抗 OVX 小鼠中骨形成的减少。
总的来说，这些发现强调了 METTL14/SLC25A3 信号轴在成骨细胞活性中的关键作用，表明该信号轴可能是改善骨质疏松症的潜在靶点。
