Heisterberg L, Møller B R, Manthorpe T, Sørensen S S, Petersen K, Nielsen N C
Sex Transm Dis. 1985 Apr-Jun;12(2):72-5. doi: 10.1097/00007435-198504000-00004.
A clinical, controlled trial was performed to study the effect of prophylaxis with lymecycline and the role of Chlamydia trachomatis and Mycoplasma hominis in postabortal genital infection. Of 532 women who were to undergo first-trimester abortion, 269 were randomized to treatment with oral lymecycline (300 mg bid) starting 2 days before the abortion and continuing for a total of 7 days, and 263 were randomized to placebo treatment. The rate of postabortal infection was 9.3% in the antibiotic group and 9.5% in the placebo group, an insignificant difference (P greater than .8). The presence of C. trachomatis in the cervix/urethra at the time of abortion showed a significant association with the occurrence of postabortal infection (P less than .005), but there was no correlation between the effect of treatment and the presence of infection (P greater than .4). The presence of M. hominis, a history of pelvic inflammatory disease, maternal age, gestational age, the number of births, spontaneous and induced abortion, and the Hegar number showed no significant association with postabortal infection (all P values greater than .05). It is recommended that women who are to undergo induced abortion be examined for the presence of C. trachomatis and treated, as they constitute a risk group.
进行了一项临床对照试验，以研究用赖甲环素进行预防的效果以及沙眼衣原体和人型支原体在流产后生殖器感染中的作用。在532名计划进行早孕流产的妇女中，269名被随机分配接受口服赖甲环素治疗（300毫克，每日两次），从流产前2天开始，持续共7天；263名被随机分配接受安慰剂治疗。抗生素组流产后感染率为9.3%，安慰剂组为9.5%，差异无统计学意义（P大于0.8）。流产时宫颈/尿道中沙眼衣原体的存在与流产后感染的发生显著相关（P小于0.005），但治疗效果与感染的存在之间无相关性（P大于0.4）。人型支原体的存在、盆腔炎病史、产妇年龄、孕周、产次、自然流产和人工流产以及黑加征与流产后感染均无显著相关性（所有P值均大于0.05）。建议对计划进行人工流产的妇女检查是否存在沙眼衣原体并进行治疗，因为她们属于高危人群。
