移动医疗技术对尼日利亚拉各斯未接种 HPV 疫苗 9-14 岁女孩的母亲接种 HPV 疫苗的影响（mHealth-HPVac）：一项随机对照试验的研究方案。

Impact of mobile health technologies on human papillomavirus vaccination uptake among mothers of unvaccinated girls aged 9-14 years in Lagos, Nigeria (mHealth-HPVac): study protocol of a randomised controlled trial.

机构信息

Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos University Teaching Hospital, PMB 12003, Surulere, Lagos, Nigeria.

Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Surulere, Lagos, Nigeria.

出版信息

BMC Cancer. 2024 Jun 20;24(1):751. doi: 10.1186/s12885-024-12538-6.

DOI:10.1186/s12885-024-12538-6

PMID:38902718

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11191157/

Abstract

BACKGROUND

Despite the availability of effective vaccines, human papillomavirus (HPV) vaccine uptake remains low in most resource-limited settings including Nigeria. Mobile health technology (mHealth) has the potential to empower patients to manage their health, reduce health disparities, and enhance the uptake of HPV vaccination.

AIM

The "mHealth-HPVac" study will assess the effects of mHealth using short text messages on the uptake of HPV vaccination among mothers of unvaccinated girls aged 9-14 years and also determine the factors influencing the uptake of HPV vaccination among these mothers.

METHODS

This protocol highlights a randomised controlled trial involving women aged 25-65 years who will be enrolled on attendance for routine care at the General Outpatient clinics of Lagos University Teaching Hospital, Lagos, Nigeria between July and December 2024. At baseline, n = 123 women will be randomised to either a short text message or usual care (control) arm. The primary outcome is vaccination of the participant's school-age girl(s) at any time during the 6 months of follow-up. The associations between any two groups of continuous variables will be assessed using the independent sample t-test for normally distributed data, or the Mann-Whitney U test for skewed data. For two groups of categorical variables, the Chi-square (X2) test or Fisher's exact test will be used, as appropriate. Using the multivariable binary logistic regression model, we will examine the effects of all relevant sociodemographic and clinical variables on HPV vaccination uptake among mothers of unvaccinated but vaccine-eligible school-age girls. Statistical significance will be reported as P < 0.05.

DISCUSSION

The mHealth-Cervix study will evaluate the impact of mobile technologies on HPV vaccination uptake among mothers of unvaccinated but vaccine-eligible school-age girls in Lagos, Nigeria as a way of contributing to the reduction in the wide disparities in cervical cancer incidence through primary prevention facilitated using health promotion to improve HPV vaccination uptake.

REGISTRATION

PACTR202406727470443 (6th June 2024).

摘要

背景

尽管有有效的疫苗，但在包括尼日利亚在内的大多数资源有限的环境中，人乳头瘤病毒（HPV）疫苗的接种率仍然很低。移动医疗技术（mHealth）有可能使患者能够管理自己的健康，减少健康差距，并提高 HPV 疫苗接种率。

目的

“mHealth-HPVac”研究将评估使用短文本消息对未接种 HPV 疫苗的 9-14 岁女孩的母亲接种 HPV 疫苗的影响，并确定影响这些母亲接种 HPV 疫苗的因素。

方法

本方案突出了一项随机对照试验，涉及年龄在 25-65 岁的妇女，她们将在 2024 年 7 月至 12 月期间在尼日利亚拉各斯大学教学医院的普通门诊就诊时参加研究。在基线时，123 名妇女将被随机分配到短信组或常规护理（对照组）。主要结局是在 6 个月的随访期间，参与者的学龄女孩（s）随时接种疫苗。使用独立样本 t 检验评估正态分布数据中任意两组连续变量之间的关联，或使用曼-惠特尼 U 检验评估偏态数据中任意两组连续变量之间的关联。对于两组分类变量，将使用卡方（X2）检验或 Fisher 确切检验，视情况而定。使用多变量二项逻辑回归模型，我们将检查所有相关社会人口统计学和临床变量对未接种但有资格接种疫苗的学龄女孩的母亲接种 HPV 疫苗的影响。统计显著性将报告为 P<0.05。