双向启动子调控的分子模型。
Molecular models of bidirectional promoter regulation.
机构信息
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.
出版信息
Curr Opin Struct Biol. 2024 Aug;87:102865. doi: 10.1016/j.sbi.2024.102865. Epub 2024 Jun 20.
Approximately 11% of human genes are transcribed by a bidirectional promoter (BDP), defined as two genes with <1 kb between their transcription start sites. Despite their evolutionary conservation and enrichment for housekeeping genes and oncogenes, the regulatory role of BDPs remains unclear. BDPs have been suggested to facilitate gene coregulation and/or decrease expression noise. This review discusses these potential regulatory functions through the context of six prospective underlying mechanistic models: a single nucleosome free region, shared transcription factor/regulator binding, cooperative negative supercoiling, bimodal histone marks, joint activation by enhancer(s), and RNA-mediated recruitment of regulators. These molecular mechanisms may act independently and/or cooperatively to facilitate the coregulation and/or decreased expression noise predicted of BDPs.
约有 11%的人类基因由双向启动子（BDP）转录，BDP 的定义为两个基因的转录起始位点之间的距离小于 1kb。尽管 BDP 具有进化保守性，并且富集了管家基因和癌基因，但它们的调控作用仍不清楚。BDP 被认为可以促进基因的共调控和/或降低表达噪声。本综述通过以下六种潜在的基础机制模型来讨论这些潜在的调控功能：单个无核小体区域、共享转录因子/调节剂结合、协同负超螺旋、双峰组蛋白标记、增强子（s）的联合激活，以及 RNA 介导的调节剂募集。这些分子机制可能独立或协同作用，以促进 BDP 预测的共调控和/或降低表达噪声。
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