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人造上臂动静脉移植物与肱动脉-头静脉内瘘在血液透析通路中的应用效果比较。

Outcomes of prosthetic upper arm arteriovenous graft vs brachiobasilic fistula for hemodialysis access.

机构信息

Division of Vascular Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

Division of Vascular Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

出版信息

J Vasc Surg. 2024 Oct;80(4):1083-1089.e2. doi: 10.1016/j.jvs.2024.05.046. Epub 2024 Jun 21.

Abstract

OBJECTIVE

Primary arteriovenous access such as radiocephalic and brachiocephalic fistulas are initial choices for creating vascular access in dialysis patients. When neither of these choices is an option, upper arm arteriovenous graft or brachiobasilic transposition is recommended. Although primary fistula is better than prosthetic graft for suitable patients, there is little data to guide the best treatment strategy in the absence of suitable vein for primary access creation. This study identifies factors that influence patency rates and compares outcomes of patients treated with brachiobasilic fistula vs upper arm graft in patients who have failed forearm access or are not candidates for primary access.

METHODS

A prospectively maintained database of patients with dialysis-dependent renal failure from 2010 to 2022 was analyzed. Primary, primary assisted, and secondary patency rates were calculated. Incidence rates of complications and reinterventions were compared.

RESULTS

There were 148 patients with brachiobasilic fistulas and 157 patients with upper arm grafts. The graft group was older (70.1 ± 14.7 vs 62.5 ± 14.6 years; P = .003) and had a higher incidence of pacemakers (11.9% vs 4.1%; P = .005). Brachiobasilic fistulas had higher 6-month (77.0% vs 64.3%; P = .02) and 1-year (68.2% vs 55.4%; P = .03) primary-assisted patency. Secondary patency rates were better for upper arm grafts at 1-year (82.2% vs 72.3%; P = .05). Access complications of non-maturation and aneurysm were higher in basilic vein transposition (21.6% vs 1.3%; P < .0001; 15.5% vs 6.4%; P = .017). Grafts had higher rates of occlusion (58.0% vs 25.7%; P < .0001). In terms of interventions, upper arm grafts had higher rates of thrombectomy (50.3% vs 18.9%; P < .0001), but there was no difference seen in angioplasty, stent, surgical revision, or steal procedures. Basilic vein transpositions had longer time to cannulation (104.6 ± 81.1 vs 32.5 ± 22.4 days; P < .0001), longer total catheter days (251.1 ± 181.7 vs 72.9 ± 56.3 days; P < .0001), and higher number of procedures to aid maturity (0.7 ± 0.7 vs 0.1 ± 0.3; P < .0001).

CONCLUSIONS

In this retrospective analysis, when forearm access or primary arteriovenous access is not an option, basilic vein transposition and upper arm grafts have fairly equivalent primary patency. Primary assisted patency is slightly better in basilic vein fistulas, but secondary patency is better in upper arm grafts at 1 year. Basilic fistulas also had longer time to cannulation, longer total catheter days, and more procedures to aid maturity.

摘要

目的

在透析患者中,初次动静脉通路如头静脉和肱动脉瘘是创建血管通路的首选。当这两种选择都不适用时,建议使用上臂动静脉移植物或肱动脉-正中静脉转位。虽然对于合适的患者来说,原发性瘘优于假体移植物,但在没有合适的静脉用于初次通路创建的情况下,几乎没有数据可以指导最佳治疗策略。本研究确定了影响通畅率的因素,并比较了在桡动脉或肱动脉通路失败或不适合初次通路的患者中,使用肱动脉-正中静脉转位和上臂移植物治疗的患者的结局。

方法

对 2010 年至 2022 年期间患有透析依赖性肾衰竭的患者进行了前瞻性维护的数据库分析。计算了原发性、原发性辅助和继发性通畅率。比较了并发症和再介入的发生率。

结果

共有 148 例患者接受了肱动脉-正中静脉转位,157 例患者接受了上臂移植物。移植物组年龄更大(70.1±14.7 岁 vs. 62.5±14.6 岁;P=0.003),起搏器的发生率更高(11.9% vs. 4.1%;P=0.005)。肱动脉-正中静脉转位在 6 个月(77.0% vs. 64.3%;P=0.02)和 1 年(68.2% vs. 55.4%;P=0.03)时的原发性辅助通畅率更高。1 年时上臂移植物的继发性通畅率更好(82.2% vs. 72.3%;P=0.05)。转位的贵要静脉存在非成熟和动脉瘤等通路并发症的发生率更高(21.6% vs. 1.3%;P<0.0001;15.5% vs. 6.4%;P=0.017)。移植物的闭塞发生率更高(58.0% vs. 25.7%;P<0.0001)。在干预方面,上臂移植物的血栓切除术发生率更高(50.3% vs. 18.9%;P<0.0001),但血管成形术、支架、手术修正或窃血手术的发生率没有差异。贵要静脉转位的置管时间更长(104.6±81.1 天 vs. 32.5±22.4 天;P<0.0001),总导管天数更长(251.1±181.7 天 vs. 72.9±56.3 天;P<0.0001),并且需要更多的辅助成熟手术(0.7±0.7 次 vs. 0.1±0.3 次;P<0.0001)。

结论

在这项回顾性分析中,当桡动脉或肱动脉通路不可用时,贵要静脉转位和上臂移植物的原发性通畅率相当。贵要静脉瘘的原发性辅助通畅率略高,但 1 年时上臂移植物的继发性通畅率更好。贵要静脉瘘还需要更长的置管时间、更长的总导管天数和更多的辅助成熟手术。

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