The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Sci Rep. 2024 Jun 23;14(1):14440. doi: 10.1038/s41598-024-65111-3.
To use Optical Coherence Tomography (OCT) to measure scleral thickness (ST) and subfoveal choroid thickness (SFCT) in patients with Branch Retinal Vein Occlusion (BRVO) and to conduct a correlation analysis. A cross-sectional study was conducted. From May 2022 to December 2022, a total of 34 cases (68 eyes) of untreated unilateral Branch Retinal Vein Occlusion (BRVO) patients were recruited at the Affiliated Eye Hospital of Nanchang University. Among these cases, 31 were temporal branch vein occlusions, 2 were nasal branch occlusions, and 1 was a superior branch occlusion. Additionally, 39 cases (39 eyes) of gender- and age-matched control eyes were included in the study. Anterior Segment Optical Coherence Tomography (AS-OCT) was used to measure ST at 6 mm superior, inferior, nasal, and temporal to the limbus, while Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT) was used to measure SFCT. The differences in ST and SFCT between the affected eye, contralateral eye, and control eye of BRVO patients were compared and analyzed for correlation. The axial lengths of the BRVO-affected eye, contralateral eye, and control group were (22.92 ± 0.30) mm, (22.89 ± 0.32) mm and (22.90 ± 0.28) mm respectively, with no significant difference in axial length between the affected eye and contralateral eye (P > 0.05). The SFCT and ST measurements in different areas showed significant differences between the BRVO-affected eye, contralateral eye in BRVO patients (P < 0.05). The CRT of BRVO-affected eyes was significantly higher than that of the contralateral eyes and the control eyes (P < 0.001). In comparison between BRVO-affected eyes and control eyes, there were no statistically significant differences in age and axial length between the two groups (P > 0.05). However, significant differences were observed in SFCT and temporal, nasal, superior, and inferior ST between the two groups (P < 0.05). The difference in temporal ST between the contralateral eyes and the control eyes was not statistically significant (t = - 0.35, P = 0.73). However, the contralateral group showed statistically significant increases in SFCT, nasal, superior and inferior ST compared to control eyes (t = - 3.153, 3.27, 4.21, 4.79, P = 0.002, 0.002, < 0.001, < 0.001). However, the difference between the CRT of the contralateral and control eyes was not statistically significant (P = 0.421). When comparing SFCT and ST between BRVO-affected eyes with and without macular edema, no statistically significant differences were found (t = - 1.10, 0.45, - 1.30, - 0.30, 1.00; P = 0.28, 0.66, 0.21, 0.77, 0.33). The thickness of SFCT and temporal ST in major BRVO group is higher than the macular BRVO group and the difference was statistically significant (t = 6.39, 7.17, P < 0.001 for all). Pearson correlation analysis revealed that in BRVO patients, there was a significant positive correlation between SFCT/CRT and temporal ST (r = 0.288, 0.355, P = 0.049, 0.04). However, there was no correlation between SFCT/CRT and nasal ST, superior ST, and inferior ST (P > 0.05). In BRVO patients, both SFCT/CRT and ST increase, and there is a significant correlation between SFCT/CRT and the ST at the site of vascular occlusion.
使用光相干断层扫描（OCT）测量视网膜分支静脉阻塞（BRVO）患者巩膜厚度（ST）和脉络膜下厚度（SFCT），并进行相关性分析。这是一项横断面研究。研究纳入了 2022 年 5 月至 2022 年 12 月期间南昌大学附属医院未接受治疗的单侧 BRVO 患者 34 例（68 只眼）。其中，31 例为颞侧分支静脉阻塞，2 例为鼻侧分支阻塞，1 例为上侧分支阻塞。此外，研究还纳入了 39 例（39 只眼）性别和年龄匹配的对照眼。使用眼前节光学相干断层扫描（AS-OCT）测量巩膜厚度，在距角膜缘上、下、鼻、颞侧 6mm 处测量，使用增强深度成像光学相干断层扫描（EDI-OCT）测量脉络膜下厚度。比较 BRVO 患者患眼、对侧眼和对照组眼的 ST 和 SFCT 差异，并进行相关性分析。BRVO 患眼、对侧眼和对照组眼的眼轴长度分别为（22.92±0.30）mm、（22.89±0.32）mm 和（22.90±0.28）mm，患眼与对侧眼的眼轴长度无显著差异（P＞0.05）。BRVO 患者患眼、对侧眼和对照组眼不同部位的 SFCT 和 ST 测量值均有显著差异（P＜0.05）。BRVO 患眼的 CRT 明显高于对侧眼和对照组眼（P＜0.001）。与对照组眼相比，BRVO 患眼的年龄和眼轴长度无统计学差异（P＞0.05）。然而，两组间 SFCT 以及颞侧、鼻侧、上侧和下侧 ST 存在显著差异（P＜0.05）。对侧眼与对照组眼的颞侧 ST 差异无统计学意义（t=-0.35，P=0.73）。然而，对侧组与对照组相比，SFCT、鼻侧、上侧和下侧 ST 均有统计学意义（t=-3.153，3.27，4.21，4.79，P=0.002，0.002，＜0.001，＜0.001）。然而，对侧眼和对照组眼的 CRT 差异无统计学意义（P=0.421）。比较 BRVO 患眼和无黄斑水肿眼的 SFCT 和 ST，无统计学差异（t=-1.10，0.45，-1.30，-0.30，1.00；P=0.28，0.66，0.21，0.77，0.33）。大 BRVO 组 SFCT 和颞侧 ST 厚度高于黄斑 BRVO 组，差异有统计学意义（t=6.39，7.17，P＜0.001）。Pearson 相关性分析显示，BRVO 患者 SFCT/CRT 与颞侧 ST 呈显著正相关（r=0.288，0.355，P=0.049，0.04）。然而，SFCT/CRT 与鼻侧 ST、上侧 ST 和下侧 ST 之间无相关性（P＞0.05）。BRVO 患者 SFCT/CRT 和 ST 均增加，SFCT/CRT 与血管阻塞部位的 ST 呈显著相关性。
