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四神丸通过调节肾-肠菌代谢途径抑制腹泻小鼠的肠道炎症。

Sishen Pill inhibits intestinal inflammation in diarrhea mice via regulating kidney-intestinal bacteria-metabolic pathway.

作者信息

Li Xiaoya, Qiao Bo, Wu Yueying, Deng Na, Yuan Jiali, Tan Zhoujin

机构信息

School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.

Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Changsha, Hunan, China.

出版信息

Front Pharmacol. 2024 Jun 10;15:1360589. doi: 10.3389/fphar.2024.1360589. eCollection 2024.

DOI:10.3389/fphar.2024.1360589
PMID:38915463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11194372/
Abstract

BACKGROUND: Sishen Pill (SSP) has good efficacy in diarrhea with deficiency kidney-yang syndrome (DKYS), but the mechanism of efficacy involving intestinal microecology has not been elucidated. OBJECTIVE: This study investigated the mechanism of SSP in regulating intestinal microecology in diarrhea with DKYS. METHODS: Adenine combined with was used to construct a mouse model of diarrhea with DKYS and administered with SSP. The behavioral changes and characteristics of gut content microbiota and short-chain fatty acids (SCFAs) of mice were analyzed to explore the potential association between the characteristic bacteria, SCFAs, intestinal inflammatory and kidney function-related indicators. RESULTS: After SSP intervention, the body weight and anal temperature of diarrhea with DKYS gradually recovered and approached the normal level. was significantly enriched, and propionic, butyric, isobutyric and isovaleric acids were elevated. Serum creatinine (Cr), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) levels of the mice were reduced, while serum blood urea nitrogen (BUN) and secretory immunoglobulin A (sIgA) in the colonic tissues were increased. Moreover, there were correlations between , SCFAs, intestinal inflammatory, and kidney function. CONCLUSION: SSP might suppress the intestinal inflammation by regulating the "-propionic acid" pathway, thus achieving the effect of treating diarrhea with DKYS.

摘要

背景：四神丸（SSP）对肾阳虚泄泻证（DKYS）有良好疗效，但涉及肠道微生态的疗效机制尚未阐明。 目的：本研究探讨SSP对DKYS泄泻肠道微生态的调节机制。 方法：采用腺嘌呤联合（此处原文缺失部分内容）构建DKYS泄泻小鼠模型，并给予SSP。分析小鼠的行为变化、肠道内容物微生物群和短链脂肪酸（SCFAs）的特征，以探讨特征菌、SCFAs、肠道炎症和肾功能相关指标之间的潜在关联。 结果：SSP干预后，DKYS泄泻小鼠的体重和肛温逐渐恢复并接近正常水平。（此处原文缺失部分内容）显著富集，丙酸、丁酸、异丁酸和异戊酸升高。小鼠血清肌酐（Cr）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平降低，而结肠组织中的血清尿素氮（BUN）和分泌型免疫球蛋白A（sIgA）增加。此外，（此处原文缺失部分内容）、SCFAs、肠道炎症和肾功能之间存在相关性。 结论：SSP可能通过调节“-丙酸”途径抑制肠道炎症，从而达到治疗DKYS泄泻的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/7219f03ac53d/fphar-15-1360589-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/a833f4abda32/fphar-15-1360589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/d041b4cfa484/fphar-15-1360589-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/62c1893a0505/fphar-15-1360589-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/04e5129ebdeb/fphar-15-1360589-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/1c8b30f0be46/fphar-15-1360589-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/3215c7092ca4/fphar-15-1360589-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/01f624260daf/fphar-15-1360589-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/b960f2e4a7b5/fphar-15-1360589-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/3b2e17c73e40/fphar-15-1360589-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/7219f03ac53d/fphar-15-1360589-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/a833f4abda32/fphar-15-1360589-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/d041b4cfa484/fphar-15-1360589-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/62c1893a0505/fphar-15-1360589-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/04e5129ebdeb/fphar-15-1360589-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/1c8b30f0be46/fphar-15-1360589-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/3215c7092ca4/fphar-15-1360589-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/01f624260daf/fphar-15-1360589-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/b960f2e4a7b5/fphar-15-1360589-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/3b2e17c73e40/fphar-15-1360589-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9481/11194372/7219f03ac53d/fphar-15-1360589-g010.jpg

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Front Cell Infect Microbiol. 2025-8-14

[2]
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[3]
Commentary: Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.

Front Cell Infect Microbiol. 2025-8-13

[4]
TMAO Activates the NLRP3 Inflammasome, Disrupts Gut-Kidney Interaction, and Promotes Intestinal Inflammation.

Int J Mol Sci. 2025-8-1

[5]
Effect of Sodium Butyrate and Sishen Pill Combination on Diarrhea with Kidney-Yang Deficiency Syndrome Was Associated with Intestinal Mucosal Microbiota and Immune Barrier.

J Inflamm Res. 2025-8-4

[6]
One of the Short-Chain Fatty Acids (SCFAs), Sodium Propionate, Can Reduce the Dosage of Sishen Pill in Regulating the Intestinal Microbiota in Diarrhea with Kidney-Yang Deficiency Syndrome.

J Inflamm Res. 2025-6-5

[7]
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[8]
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[9]
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本文引用的文献

[1]
Adenine's impact on mice's gut and kidney varies with the dosage administered and relates to intestinal microorganisms and enzyme activities.

3 Biotech. 2024-3

[2]
The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease.

Front Immunol. 2022

[3]
Sishen Pill Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis with Spleen-Kidney Yang Deficiency Syndromes: Role of Gut Microbiota, Fecal Metabolites, Inflammatory Dendritic Cells, and TLR4/NF-B Pathway.

Evid Based Complement Alternat Med. 2022-10-3

[4]
Gut-Kidney Impairment Process of Adenine Combined with -Induced Diarrhea: Association with Interactions between , and Acetic Acid, Inflammation, and Kidney Function.

Cells. 2022-10-17

[5]
Importance of in improving the adverse effects of high-fat diet on mice associated with intestinal contents microbiota.

Front Nutr. 2022-7-28

[6]
Correlation Between Kidney Function and Intestinal Biological Characteristics of Adenine and Folium SennaeInduced Diarrhea Model in Mice.

Turk J Gastroenterol. 2023-1

[7]
Anemone chinensis Bunge aqueous enema alleviates dextran sulfate sodium-induced colitis via inhibition of inflammation and regulation of the colonic mucosal microbiota.

J Ethnopharmacol. 2022-4-24

[8]
Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome.

Front Cell Infect Microbiol. 2021

[9]
Lactobacillus johnsonii activates porcine monocyte derived dendritic cells maturation to modulate Th cellular immune response.

Cytokine. 2021-8

[10]
The Gut Microbiota and Inflammation: An Overview.

Int J Environ Res Public Health. 2020-10-19

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