Edamadaka Yeshwanth, Parghane Rahul V, Basu Sandip
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra, India.
Radiation medicine center (BARC), Homi Bhabha National Institute, Mumbai, Maharashtra, India.
World J Nucl Med. 2024 Apr 1;23(2):130-134. doi: 10.1055/s-0044-1779750. eCollection 2024 Jun.
Differentiated thyroid carcinoma (DTC) usually is slow growing and carries a good prognosis. It most commonly tends to spread locally to regional lymph nodes in 20 to 60% of patients. The presence of distant metastasis impacts overall survival and prognosis. The lungs, bones, and the brain are typically involved in distant sites with less common metastatic sites that include the liver, kidney, skeletal muscle, adrenal glands, bladder, and skin. These unusual sites are rare and pose a diagnostic challenge and impact clinical decision-making to a great extent. The radioiodine I whole-body scintigraphy with single-photon emission computed tomography/computed tomography can provide a thorough investigation of unusual sites of uptake leading to diagnosis of these metastases. We present a case series of DTC showing unusual sites of metastasis and/or radioiodine uptake in urinary bladder, in the third metacarpal bone of left hand and lastly in the forearm at postoperative hypertrophic scar area.
分化型甲状腺癌（DTC）通常生长缓慢，预后良好。在20%至60%的患者中，它最常倾向于局部扩散至区域淋巴结。远处转移的存在会影响总体生存率和预后。肺、骨和脑是常见的远处转移部位，较少见的转移部位包括肝、肾、骨骼肌、肾上腺、膀胱和皮肤。这些不寻常的部位很少见，在很大程度上构成了诊断挑战并影响临床决策。单光子发射计算机断层扫描/计算机断层扫描的放射性碘I全身闪烁扫描可以对不寻常的摄取部位进行全面检查，从而诊断这些转移灶。我们展示了一组DTC病例系列，其转移和/或放射性碘摄取的不寻常部位分别位于膀胱、左手第三掌骨，最后是术后肥厚性瘢痕区域的前臂。
