Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China.
Zhejiang Hexin New Material Co., Ltd., Jiaxing 314000, China.
Biointerphases. 2024 May 1;19(3). doi: 10.1116/6.0003710.
This study aims to explore the essential functional requirements associated with controlling the proliferation of microbes in the domain of textiles used in public health areas. Herein, three antimicrobial agents, specifically iodopropylbutylcarbamate (IPBC), 1-hydroxypyridine-2-thioketone zinc (ZPT), and 2-octyl-3-isothiazolinone (OIT), were chosen for fabric finishing based on their notable effectiveness, minimal toxicity, cost-efficiency, and chemical stability. Utilizing Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) as representative bacterial strains, the Minimum Inhibitory Concentration (MIC50) of individual and combined antimicrobial agents was measured, and their antimicrobial effectiveness was rigorously evaluated. Concurrently, the antimicrobial effectiveness, whiteness, and mechanical durability of the fabric following antimicrobial treatment were thoroughly examined. The results demonstrate that some combinations of the three antimicrobial agents elicit additive effects on both S. aureus and E. coli. Notably, at an equivalent ratio of IPBC, ZPT, and OIT and a total concentration of 0.2 wt. %, the inhibition rates against both bacterial strains surpass 99%. Upon application to nylon fabric, the treated material demonstrates significant antimicrobial properties, with minimal reduction observed in the whiteness and tensile strength of the treated nylon. This study provides practicable strategies relevant to the production of textiles endowed with antimicrobial properties.
本研究旨在探索与公共卫生领域纺织品中微生物增殖控制相关的基本功能要求。本文选择了三种抗菌剂,即碘丙基丁基卡巴酯(IPBC)、1-羟基吡啶-2-硫酮锌(ZPT)和 2-辛基-3-异噻唑啉酮(OIT),用于织物整理,因为它们具有显著的效果、最小的毒性、成本效益和化学稳定性。本文使用金黄色葡萄球菌(S. aureus)和大肠杆菌(E. coli)作为代表性细菌菌株,测量了单独和组合抗菌剂的最小抑菌浓度(MIC50),并对其抗菌效果进行了严格评估。同时,还对经过抗菌处理后的织物的抗菌效果、白度和机械耐久性进行了全面检查。结果表明,三种抗菌剂的某些组合对金黄色葡萄球菌和大肠杆菌都有相加作用。值得注意的是,在 IPBC、ZPT 和 OIT 的当量比和总浓度为 0.2wt.%时,对两种细菌的抑制率均超过 99%。将其应用于尼龙织物上,处理后的材料表现出显著的抗菌性能,处理后的尼龙的白度和拉伸强度仅略有下降。本研究为生产具有抗菌性能的纺织品提供了实用的策略。