寡克隆带。
Oligoclonal bands.
机构信息
Helen Durham Centre for Neuroinflammatory Disease, Department of Neurology, University Hospital of Wales, Cardiff, UK
Helen Durham Centre for Neuroinflammatory Disease, Department of Neurology, University Hospital of Wales, Cardiff, UK.
出版信息
Pract Neurol. 2024 Sep 13;24(5):400-406. doi: 10.1136/pn-2023-003814.
Oligoclonal bands (OCBs) represent the presence of intrathecal immunoglobulin G (IgG) as detected by isoelectric focusing and immunofixation. Cerebrospinal fluid (CSF) analysed alongside a paired serum sample gives five different immunofixation patterns. These are: type 1-the normal physiological state with no intrathecal IgG synthesis; type 2-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs; type 3-evidence for intrathecal IgG synthesis, with CSF-restricted OCBs, but with additional, identical bands in the CSF and serum; type 4-absence of intrathecal IgG synthesis, but with identical OCBs in CSF and serum; and type 5-absence of intrathecal IgG synthesis, with a monoclonal band in CSF and serum. Analysis of these patterns can help to diagnose a range of neurological conditions, including multiple sclerosis. However, it is important to interpret OCB results alongside other CSF tests and their clinical context.
寡克隆带（OCB）代表存在鞘内免疫球蛋白 G（IgG），可通过等电聚焦和免疫固定检测到。与配对血清样本一起分析的脑脊液（CSF）给出了五种不同的免疫固定模式。这些模式是：1 型 - 无鞘内 IgG 合成的正常生理状态；2 型 - 有鞘内 IgG 合成的证据，CSF 中有受限的 OCB；3 型 - 有鞘内 IgG 合成的证据，CSF 中有受限的 OCB，但 CSF 和血清中还有相同的额外带；4 型 - 无鞘内 IgG 合成，但 CSF 和血清中存在相同的 OCB；5 型 - 无鞘内 IgG 合成，CSF 和血清中有单克隆带。分析这些模式可以帮助诊断一系列神经系统疾病，包括多发性硬化症。然而，重要的是要将 OCB 结果与其他 CSF 测试及其临床背景一起解释。
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