Igarashi Y, Suzuki H, Itaya Y, Kondo K, Saruta T
J Hypertens. 1985 Apr;3(2):149-53. doi: 10.1097/00004872-198504000-00007.
Oral administration of the angiotensin I-converting enzyme inhibitor captopril produced a substantial reduction of blood pressure in DOCA-salt hypertensive rats. After oral administration of captopril (30 mg/kg), mean blood pressure decreased from 172 +/- 11 to 148 +/- 9 mmHg (P less than 0.01) in one hour and its antihypertensive effects lasted for the next seven hours. Plasma vasopressin levels showed a marked elevation in DOCA-salt hypertensive rats compared with control values (22 +/- 5 versus 5 +/- 3 pg/ml). This increase in vasopressin was significantly reduced by captopril from 25 +/- 5 to 8 +/- 6 pg/ml. In addition, whole body vascular reactivity to norepinephrine was examined. Responsiveness was at first attenuated but returned to control value in spite of reduction of both plasma vasopressin and blood pressure. Thus, captopril reduces blood pressure in DOCA-salt hypertensive rats and the fall in blood pressure is accompanied by reduction of plasma vasopressin and attenuation of vascular reactivity.
口服血管紧张素I转换酶抑制剂卡托普利可使去氧皮质酮-盐高血压大鼠的血压大幅降低。口服卡托普利（30毫克/千克）后，平均血压在1小时内从172±11毫米汞柱降至148±9毫米汞柱（P＜0.01），其降压作用在接下来的7小时内持续存在。与对照值相比，去氧皮质酮-盐高血压大鼠的血浆血管加压素水平显著升高（22±5对5±3皮克/毫升）。卡托普利可使血管加压素的这种升高显著降低，从25±5降至8±6皮克/毫升。此外，还检测了全身血管对去甲肾上腺素的反应性。反应性起初减弱，但尽管血浆血管加压素和血压均降低，仍恢复到对照值。因此，卡托普利可降低去氧皮质酮-盐高血压大鼠的血压，血压下降伴随着血浆血管加压素的降低和血管反应性的减弱。
