下颌后缩导致水平上颌前突的儿童和青少年睡眠呼吸障碍的患病率：一项病例对照研究。
Prevalence of sleep-disordered breathing in children and adolescents with large horizontal maxillary overjet due to mandibular retrognathia: a case-control study.
作者信息
Hansen Camilla, Sonnesen Liselotte, Bakke Merete, Markström Agneta
机构信息
Section of Orthodontics and Dental Sleep Clinic, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Section of Clinical Oral Physiology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
出版信息
J Clin Sleep Med. 2024 Dec 1;20(12):1871-1878. doi: 10.5664/jcsm.11248.
STUDY OBJECTIVES
The aim of the study was to examine the prevalence of sleep-disordered breathing (SDB) in children and adolescents with large overjet due to mandibular retrognathia compared to a control group.
METHODS
In this case-control study children with large overjet ≥ 6 mm due to mandibular retrognathia (study group) were compared to a group with neutral occlusion (controls). All participants underwent respiratory polygraphy (PG) and questionnaires regarding sleepiness and snoring. Differences across groups were tested by chi-square test; a general linear model adjusted for age, sex, and body mass index; and a Mann-Whitney test. Differences in results of PG were also tested by a general linear model adjusted for age, sex, and body mass index according to severity of mandibular retrognathia.
RESULTS
Thirty-seven (19 male;18 female; median age 12.3 years) participants were included in the study group and 32 (16 male;16 female; median age 12.2 years) in the control group. No significant difference in SDB assessed by PG or questionnaires between the groups was found, even though the snore index was higher in the study group ( = .051). The snore index was higher than the parent-reported snoring. Respiration rate was significantly reduced in the study group ( = .043), and estimated sleep time efficiency was significantly reduced in males compared with females ( < .001).
CONCLUSIONS
No significant differences in SDB were found between the groups even though the snore index was higher in the study group. The snore index of the PG was higher than the parent-reported snoring. Estimated sleep time efficiency was reduced in males. The study improves the understanding of risk of SDB in nonobese children with large overjet due to mandibular retrognathia and may contribute to an interdisciplinary approach to risk assessment of SDB in children with malocclusion.
CLINICAL TRIAL REGISTRATION
Registry: ClinicalTrials.gov; Name: Sleep, Upper Airway and Dental Occlusion in Children With Large Overjet; URL: https://clinicaltrials.gov/study/NCT04964830?term=NCT04964830&rank=1; Identifier: NCT04964830.
CITATION
Hansen C, Sonnesen L, Bakke M, Markström A. Prevalence of sleep-disordered breathing in children and adolescents with large horizontal maxillary overjet due to mandibular retrognathia: a case-control study. 2024;20(12):1871-1878.
研究目的
本研究旨在调查因下颌后缩导致深覆盖的儿童和青少年中睡眠呼吸障碍（SDB）的患病率，并与对照组进行比较。
方法
在这项病例对照研究中，将因下颌后缩导致深覆盖≥6mm的儿童（研究组）与中性咬合的儿童（对照组）进行比较。所有参与者均接受呼吸多导睡眠监测（PG）以及关于嗜睡和打鼾的问卷调查。通过卡方检验、调整年龄、性别和体重指数的一般线性模型以及曼-惠特尼检验来检验组间差异。根据下颌后缩的严重程度，通过调整年龄、性别和体重指数的一般线性模型来检验PG结果的差异。
结果
研究组纳入了37名参与者（19名男性，18名女性；中位年龄12.3岁），对照组纳入了32名参与者（16名男性，16名女性；中位年龄12.2岁）。尽管研究组的打鼾指数较高（P = 0.051），但两组在通过PG或问卷调查评估的SDB方面未发现显著差异。打鼾指数高于家长报告的打鼾情况。研究组的呼吸频率显著降低（P = 0.043），男性的估计睡眠时间效率与女性相比显著降低（P < 0.001）。
结论
尽管研究组的打鼾指数较高，但两组在SDB方面未发现显著差异。PG的打鼾指数高于家长报告的打鼾情况。男性的估计睡眠时间效率降低。本研究增进了对因下颌后缩导致深覆盖的非肥胖儿童中SDB风险的理解，并可能有助于采用跨学科方法对咬合不正儿童的SDB风险进行评估。
临床试验注册
注册机构：ClinicalTrials.gov；名称：深覆盖儿童的睡眠、上气道与牙合；网址：https://clinicaltrials.gov/study/NCT04964830?term=NCT04964830&rank=1；标识符：NCT04964830。
引用文献
Hansen C, Sonnesen L, Bakke M, Markström A. 因下颌后缩导致水平上颌深覆盖的儿童和青少年中睡眠呼吸障碍的患病率：一项病例对照研究。2024；20(12):1871 - 1878。
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