Yeditepe University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Istanbul, Turkey.
Maltepe University, Faculty of Medicine, Department of Neurology, Istanbul, Turkey.
Complement Ther Clin Pract. 2024 Nov;57:101881. doi: 10.1016/j.ctcp.2024.101881. Epub 2024 Jul 1.
To investigate the effect of physical exercise alone and in combination with cognitive stimulation on cognition, physical function, and quality of life in patients with Alzheimer's Disease (PwAD).
The study was a randomized controlled, single-blinded trial with pre-and post-treatment and follow-up assessments conducted at the private hospital and home environment in PwAD. Seventy-five (N = 75) participants diagnosed with AD were enrolled, but sixty (N = 60) participants (mean age 77.8 years, standard deviation (SD) 6.7) were randomized as physical exercise group (PEG) (n = 20), physical exercise and cognitive stimulation group (PE + CSG) (n = 20) and control group (CG) (n = 20). Participants in PEG and PE + CSG performed an online supervised physical exercise program (SPEP) given biweekly for 12 weeks. Additionally, the cognitive stimulation (CS) program was offered for at least three or five days for 12 weeks for PE + CSG. No treatment was given for the CG. The primary outcome measures were cognition, balance, functional mobility (FM), upper extremity muscle strength (UEMS) and lower extremity muscle strength (LEMS), and quality of life (QoL). Furthermore, depression, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were measured secondarily.
PE + CSG demonstrated significant improvement in cognition, balance, FM, UEMS, IADL and reduction in depression compared to the CG (p < 0.05). Besides, participants in the PE + CSG had statistically superior QoL and IADL than the PEG (p < 0.05).
The addition of CS to the SPEP was a safe and effective method to gain statistically significant improvements in cognition, balance, FM, UEMS, IADL, and reduction in depression in PwAD.
旨在研究单纯体育锻炼以及体育锻炼联合认知刺激对阿尔茨海默病患者（PwAD）认知、身体功能和生活质量的影响。
本研究为一项随机对照、单盲试验，在 PwAD 的私人医院和家庭环境中进行治疗前、治疗后和随访评估。共纳入 75 名（N=75）被诊断为 AD 的参与者，但有 60 名（N=60）参与者（平均年龄 77.8 岁，标准差（SD）6.7）被随机分为体育锻炼组（PEG）（n=20）、体育锻炼和认知刺激组（PE+CSG）（n=20）和对照组（CG）（n=20）。PEG 和 PE+CSG 组的参与者每周接受两次在线监督体育锻炼计划（SPEP），共 12 周。此外，PE+CSG 还提供至少三天或五天的认知刺激（CS）计划，共 12 周。CG 不进行任何治疗。主要观察指标为认知、平衡、功能移动性（FM）、上肢肌肉力量（UEMS）和下肢肌肉力量（LEMS）和生活质量（QoL）。此外，还测量了抑郁、基本日常生活活动（BADL）和工具性日常生活活动（IADL）。
与 CG 相比，PE+CSG 组在认知、平衡、FM、UEMS、IADL 方面有显著改善，抑郁程度降低（p<0.05）。此外，PE+CSG 组的参与者在 QoL 和 IADL 方面明显优于 PEG 组（p<0.05）。
在 SPEP 中加入 CS 是一种安全有效的方法，可以显著改善 PwAD 的认知、平衡、FM、UEMS、IADL 和抑郁程度。
