School of Chemistry, Dalian University of Technology, 116024, Dalian, Liaoning, China.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 116024, Dalian, Liaoning, China.
Nat Commun. 2024 Jul 3;15(1):5579. doi: 10.1038/s41467-024-49953-z.
Liquid-liquid reactions play a significant role in organic synthesis. However, control of the phase interface between incompatible two-phase liquids remains challenging. Moreover, separating liquid acid, base and oxidants from the reactor takes a long time and high cost. To address these issues, we draw inspiration from the structure and function of cells in living organisms and develop a biomimetic 3D-printed cellular reactor. The cellular reactor houses an aqueous phase containing the catalyst or oxidant while immersed in the organic phase reactant. This setup controls the distribution of the phase interface within the organic phase and increases the interface area by 2.3 times. Notably, the cellular reactor and the aqueous phase are removed from the organic phase upon completing the reaction, eliminating additional separation steps and preventing direct contact between the reactor and acidic, alkaline, or oxidizing substances. Furthermore, the cellular reactor offers the advantages of digital design feasibility and cost-effective manufacturing.
液-液相反应在有机合成中起着重要作用。然而，控制不相容两相液体之间的相界面仍然具有挑战性。此外，从反应器中分离液体酸、碱和氧化剂需要很长时间和高成本。为了解决这些问题，我们从活生物体中细胞的结构和功能中汲取灵感，开发出仿生 3D 打印细胞反应器。细胞反应器容纳含有催化剂或氧化剂的水相，同时浸入有机相反应物中。这种设置控制了有机相内相界面的分布，并将界面面积增加了 2.3 倍。值得注意的是，反应完成后，细胞反应器和水相从有机相分离，消除了额外的分离步骤，并防止反应器与酸性、碱性或氧化性物质直接接触。此外，细胞反应器具有数字设计可行性和经济高效制造的优势。
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